학술논문
Interleukin-6: Unravelling its role in sarcopenia pathogenesis and exploring therapeutic avenues
Document Type
Academic Journal
Author
Source
Pharmacia. December 8, 2023 Issue 4, p1493, 6 p.
Subject
Language
English
ISSN
0428-0296
Abstract
Author(s): Yavor Assyov (corresponding author) [1]; Iliana Ganeva [2]; Stefan Ikonomov [2]; Iveta Nedeva [1]; Toni Velikov [3]; Zdravko Kamenov [1]; Tsvetelina Velikova [4] Introduction Sarcopenia, characterized by the progressive [...]
This review explores the intricate relationship between interleukin-6 (IL-6) and sarcopenia, a prevalent condition characterized by progressive skeletal muscle loss, particularly in aging populations. Emphasizing the rising prevalence and health challenges posed by sarcopenia, the paper delves into the multifunctional roles of IL-6 in immune response, inflammation and inflammaging associated with sarcopenia. Significantly elevated in sarcopenic individuals, IL-6 prompts an exploration of its molecular impact on muscle wasting. The review critically assesses IL-6 as a potential biomarker for sarcopenia diagnosis and prognosis while also examining therapeutic interventions targeting IL-6 signaling pathways, offering a foundation for future research and the development of targeted therapeutic strategies to alleviate the impact of this debilitating condition. Keywords: Interleukin-6, Sarcopenia, Muscle wasting, Inflammation, inflammaging, Cytokines, Muscle atrophy, anti-IL-6 drugs, JAK inhibitors
This review explores the intricate relationship between interleukin-6 (IL-6) and sarcopenia, a prevalent condition characterized by progressive skeletal muscle loss, particularly in aging populations. Emphasizing the rising prevalence and health challenges posed by sarcopenia, the paper delves into the multifunctional roles of IL-6 in immune response, inflammation and inflammaging associated with sarcopenia. Significantly elevated in sarcopenic individuals, IL-6 prompts an exploration of its molecular impact on muscle wasting. The review critically assesses IL-6 as a potential biomarker for sarcopenia diagnosis and prognosis while also examining therapeutic interventions targeting IL-6 signaling pathways, offering a foundation for future research and the development of targeted therapeutic strategies to alleviate the impact of this debilitating condition. Keywords: Interleukin-6, Sarcopenia, Muscle wasting, Inflammation, inflammaging, Cytokines, Muscle atrophy, anti-IL-6 drugs, JAK inhibitors