학술논문
Relationship of serum Fetuin-A with metabolic and vascular parameters in patients with prediabetes and type 2 diabetes mellitus
Document Type
Report
Author
Source
Pharmacia. December 4, 2023 Issue 4, p1455, 7 p.
Subject
Language
English
ISSN
0428-0296
Abstract
Author(s): Vera Karamfilova (corresponding author) [1]; Iveta Nedeva (corresponding author) [1]; Tsvetan Gatev [1]; Antoaneta Gateva [1]; Yavor Assyov [1]; Antonina Gerganova [1]; Dobrin Popov [1]; Tsvetelina Velikova [2]; Zdravko [...]
Background: Fetuin-A is a multifunctional liver-derived glycoprotein that is associated with insulin resistance and might play a role in the pathogenesis of prediabetes and type 2 diabetes (T2DM). Objective: This study evaluated the relationship of Fetuin-A with metabolic and vascular parameters in patients with prediabetes and T2DM. Materials and methods: total 120 obese patients were included. They were divided into three groups: group 1 - without carbohydrate disturbances, group 2 - with prediabetes and group 3 - with type 2 diabetes mellitus. Results: Higher Fetuin-A serum levels were observed in patients with prediabetes and T2DM compared to those with normoglycemia. Fetuin-A â¥821 mcg/ml increased the risk for T2DM 32-fold. Additionally, we found positive correlations between Fetuin-A, vibration perception threshold and toe-brachial index and a negative correlation with neuropathy disability score. Conclusion: Fetuin-A could be predictive for incidents of prediabetes and T2DM. Keywords: Fetuin-A, prediabetes, type 2 diabetes mellitus, vascular parameters
Background: Fetuin-A is a multifunctional liver-derived glycoprotein that is associated with insulin resistance and might play a role in the pathogenesis of prediabetes and type 2 diabetes (T2DM). Objective: This study evaluated the relationship of Fetuin-A with metabolic and vascular parameters in patients with prediabetes and T2DM. Materials and methods: total 120 obese patients were included. They were divided into three groups: group 1 - without carbohydrate disturbances, group 2 - with prediabetes and group 3 - with type 2 diabetes mellitus. Results: Higher Fetuin-A serum levels were observed in patients with prediabetes and T2DM compared to those with normoglycemia. Fetuin-A â¥821 mcg/ml increased the risk for T2DM 32-fold. Additionally, we found positive correlations between Fetuin-A, vibration perception threshold and toe-brachial index and a negative correlation with neuropathy disability score. Conclusion: Fetuin-A could be predictive for incidents of prediabetes and T2DM. Keywords: Fetuin-A, prediabetes, type 2 diabetes mellitus, vascular parameters