학술논문
Effects of metformin on insulin resistance, androgen concentration, ovulation and pregnancy rates in women with polycystic ovary syndrome following laparoscopic ovarian drilling
Document Type
Author abstract
Author
Source
Journal of Obstetrics and Gynaecology Research. June, 2006, Vol. 32 Issue 3, p292, 7 p.
Subject
Language
English
ISSN
1341-8076
Abstract
To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1447-0756.2006.00401.x Byline: Idris Kocak, Cazip Ustun Keywords: metformin; polycystic ovary syndrome; pregnancy; surgically induced Abstract: Abstract Aim: To evaluate the effects of metformin on insulin resistance, androgen concentration, ovulation rates and pregnancy rates in infertile women with polycystic ovary syndrome (PCOS). Methods: Forty-two infertile women with PCOS were selected in this randomized clinical study. Basal steroid and gonadotropin levels were measured, and oral glucose tolerance test (OGTT) was performed. The patients were randomly divided into group 1 (n = 21) and group 2 (n = 21). Group 1 patients were treated with laparoscopic ovarian drilling (LOD). Group 2 patients underwent laparoscopic ovarian drilling (LOD) and received 1700 mg per day of metformin for 6 months. LOD was performed in women with PCOS using a unipolar electrode. Serum progesterone (P) level > 5 ng/mL was considered as a confirmation of ovulation. Ovulation and pregnancy rates were determined after six cycles. Results: Serum androgens and insulin response to OGTT decreased significantly after metformin therapy. Mean serum P levels and endometrial thickness were significantly higher in cycles treated with metformin plus LOD (34.6 [+ or -] 25.4 ng/mL, 8.4 [+ or -] 1.1 mm) than in those treated with LOD alone (26.2 [+ or -] 24.7 ng/mL, 7.9 [+ or -] 2.8 mm) (P < 0.05). The ovulation (56 of 65 cycles, 86.1% vs 29 of 65 cycles, 44.6%) and pregnancy rates (nine of 21 women, 47.6% vs four of 21 women, 19.1%) were significantly higher in group 2 than in group I. Conclusions: Metformin improves insulin resistance, reduces androgen levels and significantly increases the ovulation and pregnancy rates in infertile women, following LOD. Article History: Received: November 4 2004.Accepted: January 20 2006. Article note: Dr Idris Kocak, 100.yil. Bul. Adalet Mah. Caykara, Apt. no. 242, Samsun, Turkey. Email: idriskocak@hotmail.com