학술논문
Prevention of invasive ventilation (PRiVENT)--a prospective, mixed-methods interventional, multicentre study with a parallel comparison group: study protocol
Document Type
Report
Author
Michels, Julia D.; Meis, Jan; Sturm, Noemi; Bornitz, Florian; von Schumann, Selina; Weis, Aline; Neetz, Benjamin; Bentner, Martina; Forstner, Johanna; Litke, Nicola; Wensing, Michel; Erdmann, Stella; Grobe, Thomas; Frerk, Timm; Kempa, Axel; Neurohr, Claus; Schneider, Armin; Müller, Michael; Herth, Felix J. F.; Szecsenyi, Joachim; Trudzinski, Franziska C.; Trudzinski, Franziska Christina; Iberl, Gabriele; Müller, Beatrice; Biehler, Elena; Fleischhhauer, Thomas; Fuchs, Gerhard; Qreini, Markus; Schubert-Haack, Janina; Klingenberg, Anja; Kempa, Alex; Joves, Biljana; Rheinhold, Andreas; Ghiani, Alessandro; Lutz, Nina; Walcher, Swenja; Tsitouras, Konstantinos; Paderewska, Joanna; Briese, Selina; Andritschky, Christoph; Gehrig, Patrick; Sugg, Joachim; Hirschmann, Susanne; Britsch, Simone; Straub, Christa; Jabbour, Claude; Hahn, Michael; Krebs, Jörg; Graf, Peter-Tobias; Denzer, Petra; Fiedler, Mascha O.; Bomeken, Miriane; Stier, Sebastian; Terboven, Tom; Merle, Uta; Regula, Jens; Müller, Jens; Oltmanns, Ute; Hennersdorf, Marcus; Satir, Neslihan; Borst, Mathias; Mayer, Brigitte; Reikow, Wolfgang; Kredel, Markus; Frey, Konstantin; Wolff, Holger; Seidlitz, Florian; Bientzle, Stefanie; Nohé, Boris; Allgäuer, Sebastian; Schöpp, Alexej; Schlegel, Christoph; Hübner, Imke; Kuzniar, Andrezj; Häberle, Helene; Riessen, Reimer; Schempf, Benjamin; Rebenschütz, Ingo; Straub, Andreas; Kollum, Marc; Winter, Markus; Hartveg, Paul; Junginger, Andreas; Beck, Helmut; Vogel, Mathias
Source
BMC Health Services Research. March 30, 2023, Vol. 23 Issue 1
Subject
Language
English
ISSN
1472-6963
Abstract
Author(s): Julia D. Michels[sup.1,2] , Jan Meis[sup.3] , Noemi Sturm[sup.4] , Florian Bornitz[sup.5] , Selina von Schumann[sup.4] , Aline Weis[sup.4] , Benjamin Neetz[sup.1] , Martina Bentner[sup.4] , Johanna Forstner[sup.4] , [...]
Background Invasive mechanical ventilation (IMV) is a standard therapy for intensive care patients with respiratory failure. With increasing population age and multimorbidity, the number of patients who cannot be weaned from IMV increases, resulting in impaired quality of life and high costs. In addition, human resources are tied up in the care of these patients. Methods The PRiVENT intervention is a prospective, mixed-methods interventional, multicentre study with a parallel comparison group selected from insurance claims data of the health insurer Allgemeine Ortskrankenkasse Baden-Württemberg (AOK-BW) conducted in Baden-Württemberg, Germany, over 24 months. Four weaning centres supervise 40 intensive care units (ICUs), that are responsible for patient recruitment. The primary outcome, successful weaning from IMV, will be evaluated using a mixed logistic regression model. Secondary outcomes will be evaluated using mixed regression models. Discussion The overall objective of the PRiVENT project is the evaluation of strategies to prevent long-term IMV. Additional objectives aim to improve weaning expertise in and cooperation with the adjacent Intensive Care Units. Trial registration This study is registered at ClinicalTrials.gov (NCT05260853). Keywords: Invasive mechanical ventilation, Weaning, Weaning failure, Respiratory failure, Medical education and training
Background Invasive mechanical ventilation (IMV) is a standard therapy for intensive care patients with respiratory failure. With increasing population age and multimorbidity, the number of patients who cannot be weaned from IMV increases, resulting in impaired quality of life and high costs. In addition, human resources are tied up in the care of these patients. Methods The PRiVENT intervention is a prospective, mixed-methods interventional, multicentre study with a parallel comparison group selected from insurance claims data of the health insurer Allgemeine Ortskrankenkasse Baden-Württemberg (AOK-BW) conducted in Baden-Württemberg, Germany, over 24 months. Four weaning centres supervise 40 intensive care units (ICUs), that are responsible for patient recruitment. The primary outcome, successful weaning from IMV, will be evaluated using a mixed logistic regression model. Secondary outcomes will be evaluated using mixed regression models. Discussion The overall objective of the PRiVENT project is the evaluation of strategies to prevent long-term IMV. Additional objectives aim to improve weaning expertise in and cooperation with the adjacent Intensive Care Units. Trial registration This study is registered at ClinicalTrials.gov (NCT05260853). Keywords: Invasive mechanical ventilation, Weaning, Weaning failure, Respiratory failure, Medical education and training