학술논문
A novel asymmetric synthesis of axial-equatorial furofuran lignans: A synthesis of (+)-fargesin
Document Type
Academic Journal
Author
Source
Tetrahedron Letters. Oct 2, 1995, Vol. 36 Issue 40, p7271, 4 p.
Subject
Language
English
ISSN
0040-4039
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/0040-4039(95)01507-E Byline: Shin-ichi Yoshida, Takeshi Yamanaka, Tutomu Miyake, Yasunori Moritani, Hiroshi Ohmizu, Tameo Iwasaki Abstract: (+)-Fargesin (6), a representative example of the axial-equatorial furofuran lignans having two different aryl groups, was efficiently synthesized based on a highly diastereoselective Michael addition reaction of the cyanohydrin 1 to methyl (S)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-cis-2-propenoate (2). Author Affiliation: Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd., 3-16-89 Kashima, Yodogawa, Osaka 532, Japan Article History: Received 13 July 1995; Revised 4 August 1995; Accepted 8 August 1995