학술논문
First stereocontrolled synthesis of unsymmetrically substituted bislactone lignans: stereocontrolled syntheses of four possible isomers of methyl 4,8-dioxanthoxylol
Document Type
Academic Journal
Source
Journal of Organic Chemistry. March 7, 1997, Vol. 62 Issue 5, p1310, 7 p.
Subject
Language
ISSN
0022-3263
Abstract
A novel method for the stereocontrolled synthesis of unsymmetrically substituted bislactone lignans was developed based on the stereoselective aldol reaction of the acid anhydride. The synthetic strategy involved the reaction of an aromatic aldehyde with an acid anhydride in the presence of methyl 4,8-dioxofargesin and methyl 4,8-dioxopipetriol. The stereocontrolled synthetic process led to the formation of four stereoisomers of bislactone furofuran lignans with different aryl groups.