학술논문
An innate antiviral pathway acting before interferons at epithelial surfaces
Document Type
Report
Author
Iversen, Marie B.; Reinert, Line S.; Thomsen, Martin K.; Bagdonaite, Ieva; Nandakumar, Ramya; Cheshenko, Natalia; Prabakaran, Thaneas; Vakhrushev, Sergey Y.; Krzyzowska, Malgosha; Kratholm, Sine K.; Ruiz-Perez, Fernando; Petersen, Steen V.; Goriely, Stanislas; Bibby, Bo Martin; Eriksson, Kristina; Ruland, Jurgen; Thomsen, Allan R.; Herold, Betsy C.; Wandall, Hans H.; Frische, Sebastian; Holm, Christian K.; Paludan, Soren R.
Source
Nature Immunology. February 1, 2016, p150, 12 p.
Subject
Language
English
ISSN
1529-2908
Abstract
Many infectious agents enter the body through routes lined with epithelium, and the mucosal surfaces therefore represent the first barrier to infection. This is true for human viral pathogens such [...]
Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate antiviral pathway that works at epithelial surfaces before the IFNs. The pathway is activated independently of known innate sensors of viral infections through a mechanism dependent on viral O-linked glycans, which induce CXCR3 chemokines and stimulate antiviral activity in a manner dependent on neutrophils. This study therefore identifies a previously unknown layer of antiviral defense that exerts its action on epithelial surfaces before the classical IFN response is operative.
Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate antiviral pathway that works at epithelial surfaces before the IFNs. The pathway is activated independently of known innate sensors of viral infections through a mechanism dependent on viral O-linked glycans, which induce CXCR3 chemokines and stimulate antiviral activity in a manner dependent on neutrophils. This study therefore identifies a previously unknown layer of antiviral defense that exerts its action on epithelial surfaces before the classical IFN response is operative.