학술논문
Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups
RESEARCH ARTICLE
RESEARCH ARTICLE
Document Type
Report
Author
Source
Turkish Journal of Colorectal Disease. June 2023, Vol. 33 Issue 2, p43, 5 p.
Subject
Language
English
ISSN
2536-4898
Abstract
Colorectal cancers (CRCs) originate from initially benign polyps identified as high-grade dysplasia (HGD) and low-grade dysplasia (LGD). (1) Elimination of polyps by polypectomy was reported to reduce CRC incidence in [...]
Aim: The risk of colorectal cancer development associated with low-grade dysplasia (LGD) and high-grade dysplasia (HGD) colon polyps at baseline polypectomy remains unclear. In this study, we investigated the role of microsatellite instability (MSI) in the formation and prognosis of dysplasia. Method: In the study, 40 polyps diagnosed as HGD, and 40 polyps diagnosed as LGD were evaluated according to the revised Vienna criteria (2015) as a result of polypectomy. MSI analysis was performed by fragment analysis using five different primers. Results: Three of the polyps diagnosed with LGD and eight of the polyps diagnosed with HGD turned into cancer during the follow-up period. The rate of MSI in sporadic colorectal dysplasia was determined as 36.3. A significant correlation was found between MSI status and polyp recurrence within the five-year follow-up period after polypectomy. Conclusion: In our study, it was determined that LGD and HGDs with MSI can recur, but polypectomy may be effective in preventing cancer formation in cases of dysplasia with MSI. Keywords: Colorectal polyps, low-grade dysplasia, high-grade dysplasia, microsatellite instability
Aim: The risk of colorectal cancer development associated with low-grade dysplasia (LGD) and high-grade dysplasia (HGD) colon polyps at baseline polypectomy remains unclear. In this study, we investigated the role of microsatellite instability (MSI) in the formation and prognosis of dysplasia. Method: In the study, 40 polyps diagnosed as HGD, and 40 polyps diagnosed as LGD were evaluated according to the revised Vienna criteria (2015) as a result of polypectomy. MSI analysis was performed by fragment analysis using five different primers. Results: Three of the polyps diagnosed with LGD and eight of the polyps diagnosed with HGD turned into cancer during the follow-up period. The rate of MSI in sporadic colorectal dysplasia was determined as 36.3. A significant correlation was found between MSI status and polyp recurrence within the five-year follow-up period after polypectomy. Conclusion: In our study, it was determined that LGD and HGDs with MSI can recur, but polypectomy may be effective in preventing cancer formation in cases of dysplasia with MSI. Keywords: Colorectal polyps, low-grade dysplasia, high-grade dysplasia, microsatellite instability