학술논문
Taurocholate induces directional excretion of bilirubin into bile in perfused rat liver
Document Type
Academic Journal
Author
Source
American Journal of Physiology (Consolidated). June 1996, Vol. 270 Issue 6, pG1028, 5 p.
Subject
Language
ISSN
0002-9513
Abstract
Taurocholate, a choleretic bile acid, enhances the transport of bilirubin from the liver into bile, in rats. In its presence, the amount of bilirubin excreted corresponds to 60% of the outflow of carbon monoxide into the bile or venous effluents. Amount of excreted bilirubin is reduced to 27% of carbon monooxide flux in the absence of taurocholate and is transported without undergoing glucuronyl conjugation. Bilirubin accumulation in the liver parenchyma is prevented by this bile acid.