부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.pediatrneurol.2005.12.005 Byline: Muneaki Matsuo ([cor]), Kazuya Sasaki ([cor]), Tomohiro Ichimaru ([cor]), Sachie Nakazato (a ), Yuhei Hamasaki ([cor]) Abstract: This study examined the possibility that children with and without a history of febrile seizures might mount different immune responses to double-stranded ribonucleic acid, which is a common viral factor that induces host cell immune responses, and is recognized by Toll-like receptor 3. The production of interleukin-1[beta] and interferon-[alpha] from double-stranded ribonucleic acid-stimulated leukocytes was examined in 27 children (age 3.6 [+ or -] 0.3 years) with a history of febrile seizures and in 18 children (age 3.4 [+ or -] 0.2 years) without a history of febrile seizures. Significantly (P = 0.0007) increased interleukin-1[beta] production was observed in children with a history of febrile seizures, compared with control subjects. When patients with a single prior episode of febrile seizures (n = 9) and those with multiple prior episodes of febrile seizures (n = 18) were compared, a significant difference in interleukin-1[beta] production was not observed. Genotyping of interleukin-1[beta](-511), Toll-like receptor 3, Toll-IL-1 receptor domain-containing adapter inducing interferon-[beta], and interleukin-1 receptor antagonist polymorphisms revealed no significant differences in allelic distribution among febrile seizure patients and control subjects. Interleukin-1[beta] production was not significantly influenced by genotype. Viral infection results in increased interleukin-1[beta] production in febrile seizure patients, and this may play a role in febrile seizures. Author Affiliation: ([cor]) Department of Pediatrics, Faculty of Medicine, Saga University, Saga, Japan (a ) Department of Laboratory Investigation, Faculty of Medicine, Saga University, Saga, Japan. Article History: Received 7 September 2005; Accepted 12 December 2005