부산대학교 도서관

To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1468-1293.2008.00687.x Byline: Y-C Lo (1), S-C Chang (2), M-Y Chen (2), W-H Sheng (2), S-M Hsieh (2), H-Y Sun (2), W-C Liu (2), P-Y Wu (2), C-H Wu (2), C-C Hung (2) Keywords: antiretroviral therapy; case-control study; diabetes mellitus; HIV infection Abstract: Objectives Recent studies suggest that patients with HIV infection are at increased risk for incident diabetes mellitus (DM). We investigated the incidence and risk factors of DM among HIV-infected patients receiving combination antiretroviral therapy (CART) in Taiwan. Methods Incident cases of DM were identified among HIV-infected patients at the National Taiwan University Hospital between 1993 and 2006. A retrospective case-control study was conducted after matching cases with controls for sex, age at HIV diagnosis, year of HIV diagnosis, mode of HIV transmission and baseline CD4 lymphocyte count. A multivariate analysis was performed to identify risk factors for incident DM among HIV-infected patients. Results In 824 HIV-infected patients eligible for analysis, 50 cases of incident DM were diagnosed, resulting in an incidence of 13.1 cases per 1000 person-years of follow-up. In total, 100 matched controls were identified. Risk factors for incident DM were a family history of DM [odds ratio (OR) 2.656; 95% confidence interval (CI) 1.209-5.834], exposure to zidovudine (OR 3.168; 95% CI 1.159-8.661) and current use of protease inhibitors (OR 2.528; 95% CI 1.186-5.389). Conclusions Incident DM was associated with a family history of DM, exposure to zidovudine and current use of protease inhibitors in HIV-infected patients receiving CART in Taiwan. Author Affiliation: (1)Centers for Disease Control, Department of Health, Taipei, Taiwan and (2)Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan Article History: Accepted 7 November 2008 Article note: Correspondence: Dr Chien-Ching Hung, Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan 100. Tel: +886 2 2123456 ext. 67552; fax: +886 2 23707772; e-mail: hcc0401@ntu.edu.tw