학술논문
Identification of a 45-kDa protein at the protein import site of the yeast mitochondrial inner membrane
Document Type
Academic Journal
Source
Proceedings of the National Academy of Sciences of the United States. Dec 15, 1992, Vol. 89 Issue 24, p11930, 5 p. photograph
Subject
Language
ISSN
0027-8424
Abstract
An investigation was conducted to identify proteins involved in the inner-membrane transport system of yeast mitochondria. The procedures involved the use of a bifunctional crosslinker to identify proteins in the immediate vicinity of precursor proteins translocated but stuck to the protein import channel of the inner membrane. In addition, a serological approach was used to isolate antibody-bound antigens which inhibit protein import. The experiments identified a 45-kDa protein designated ISP45 which is proposed to be part of the protein import system of yeast inner mitochondrial membranes.