학술논문
The strategic use of novel smallpox vaccines in the post-eradication world
Document Type
Academic Journal
Author
Source
Expert Review of Vaccines. July 2011, Vol. 10 Issue 7, p1021, 15 p.
Subject
Language
English
ISSN
1476-0584
Abstract
We still face a threat of orthopoxviruses in the form of biological weapons and emerging zoonoses. Therefore, there is a need to maintain a comprehensive defense strategy to counter the low-probability, high-impact threat of smallpox, as well as the ongoing threat of naturally occurring orthopoxvirus disease. The currently licensed live-virus smallpox vaccine ACAM2000 is effective, but associated with serious and even life-threatening adverse events. The health threat posed by this vaccine, and other previously licensed vaccines, has prevented many first responders, and even many in the military, from receiving a vaccine against smallpox. At the same time, global immunity produced during the smallpox eradication campaign is waning. Here, we review novel subunit/component vaccines and how they might play roles in unconventional strategies to defend against emerging orthopoxvirus diseases throughout the world and against smallpox used as a weapon of mass destruction.
Author(s): Joseph W Golden [sup.1] , Jay W Hooper [sup.[[dagger]]] [sup.2] Keywords : biological warfare; disease eradication; DNA vaccines; humoral immunity; orthopoxvirus; subunit vaccines; vaccination; variola virus; viral vectors; zoonoses [...]
Author(s): Joseph W Golden [sup.1] , Jay W Hooper [sup.[[dagger]]] [sup.2] Keywords : biological warfare; disease eradication; DNA vaccines; humoral immunity; orthopoxvirus; subunit vaccines; vaccination; variola virus; viral vectors; zoonoses [...]