부산대학교 도서관

Vaccination with live vaccinia virus affords long-lasting protection against variola virus, the agent of smallpox. Its mode of protection in humans, however, has not been clearly defined. Here we report that vaccinia-specific B-cell responses are essential for protection of macaques from monkeypox virus, a variola virus ortholog. Antibody-mediated depletion of B cells, but not CD4[sup.+] or CD8[sup.+] T cells, abrogated vaccine-induced protection from a lethal intravenous challenge with monkeypox virus. In addition, passive transfer of human vaccinia-neutralizing antibodies protected nonimmunized macaques from severe disease. Thus, vaccines able to induce long-lasting protective antibody responses may constitute realistic alternatives to the currently available smallpox vaccine (Dryvax).
Author(s): Yvette Edghill-Smith [1]; Hana Golding [2]; Jody Manischewitz [2]; Lisa R King [2]; Dorothy Scott [3]; Mike Bray [4]; Aysegul Nalca [5]; Jay W Hooper [6]; Chris A Whitehouse [...]