부산대학교 도서관

To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1574-6968.2007.00955.x Byline: Nancy P. Hoe (1), Ewa Lukomska (2), James M. Musser (1), Slawomir Lukomski (2,3) Keywords: group A Streptococcus; Scl; humoral response Abstract: Abstract Group A Streptococcus (GAS) infections may trigger autoimmune sequelae thought to involve streptococcal antibodies cross-reactive to human antigens. Here, the antigenicity of the streptococcal collagen-like (CL) proteins, Scl1 and Scl2, that exhibit structural similarity to human collagen, was analyzed. Antibodies to Scl1.1 protein were detected in human sera from healthy individuals previously infected with M1 GAS and from patients with various GAS infections, as well as in sera from mice infected with M1 GAS. Linear B-cell epitope mapping identified immunoreactive peptides corresponding to the CL region of Scl1.1. Humoral responses to Scl1.28 and Scl2.28 were also detected in pediatric patients and mice infected with M28 GAS. Author Affiliation: (1)Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA (2)Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA (3)Mary Babb Randolph Cancer Center, West Virginia University School of Medicine, Morgantown, WV, USA Article History: Received 29 June 2007; accepted 7 September 2007.First published online 24 October 2007. Article note: Correspondence: Slawomir Lukomski, Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, 2095 Health Sciences North, PO Box 9177, Morgantown, WV 26506, USA. Tel.: +1 304 293 6405; fax: +1 304 293 7823; e-mail: slukomski@hsc.wvu.edu