부산대학교 도서관

The objective of this study was to identify the major compounds present in Cedar tar obtained by distillation of Cedrus atlantica wood from the Taza forest (Morocco) and to evaluate its antidermatophytic activity in vitro against the three strains of dermatophytes most widespread in Morocco, considered the main prevailing causes of fungal infections of the skin, hair and nails. GC/MS analysis revealed that cedar tar is composed mainly of hydrocarbon sesquiterpenes and oxygenated sesquiterpenes, with nine major compounds identified, including [alpha]-Cedrene, [beta]-Cadinene, [gamma]-Cadinene, [beta]-Himachelene, [alpha]-Turmerone, [beta]-Turmerone, Ar-tumerone, [alpha]-Atlantone and Himachalol. The evaluation of antifungal activity was carried out by the micro dilution technique. The MIC values found were 100 [micro]g/mL, 2 [micro]g/mL and 0.1 [micro]g/mL on Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum canis strains respectively. The observed strong antifungal activity of cedar tar is attributed to the prevalence of oxygenated and hydrocarbon sesquiterpenes, known for their established antidermatophytic properties. This study highlights the potential of the Atlas Cedar tar as an effective antifungal agent for the treatment of superficial mycoses, particularly dermatophytoses. Keywords: Cedar tar, Cedrus atlantica, dermatophytes, antifungal activity, sesquiterpene
INTRODUCTION Dermatophytosis, a prevalent global infectious ailment, imposes chronic morbidity, particularly in developing nations (Ramaraj et al., 2016). This condition, caused by keratin-requiring fungi called dermatophytes, has witnessed an escalating [...]