부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neulet.2006.10.059 Byline: Zhi-Wei Xu (a), Bing Hou (a), Yun-Feng Li (b), Yan Gao (a), Zhen-Tao Su (a), Guo-Shan Yang (a), Shi-Fu Zhao (a), Fu-Chu He (a), Cheng-Gang Zhang (a) Keywords: Theophylline; Microwave; Inhibitory avoidance task; Memory impairment; Adenosine Abstract: Numerous studies have shown that acute microwave exposure causes cognitive deficits in animals, possibly via hyperthermia, but the biological effect of microwave exposure on memory processing is still unknown. The release of adenosine is demonstrated to be a general way for the cells to respond to metabolically stressful conditions such as hypoxia and ischemia. The present study aimed to examine whether adenosine mediates biological effects of microwave exposure on memory processing using a continuous multiple-trial inhibitory avoidance task. Results demonstrated that microwave exposure for 20min before training impaired memory acquisition and retention performance in mice, assessed by the number of training trials and by latency to enter the dark compartment. The mice exposed to microwave radiation showed a dose-dependent hyperthermia. Moreover, the cell numbers of hippocampus were decreased in the mice receiving microwave exposure at an average power density of 50mW/cm.sup.2, indicating the anatomical correlation to hippocampal-amygdaloid structures corresponding with the memory disrupt of the mice. Administration of theophylline, a nonspecific adenosine receptor antagonist, 30min before microwave exposure, completely antagonized the impairment of inhibitory avoidance acquisition but not retention. These results suggest that the adenosine regulation pathway was partially involved in microwave-induced impairment of inhibitory avoidance memory. Author Affiliation: (a) Beijing Institute of Radiation Medicine, Beijing 100850, China (b) Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China Article History: Received 10 January 2006; Revised 10 August 2006; Accepted 4 October 2006