학술논문
Insufficient lymph node assessment in gastric adenocarcinoma
Research
Research
Document Type
Academic Journal
Author
Source
Journal of the Egyptian National Cancer Institute. October 22, 2019, Vol. 31 Issue 1
Subject
Language
English
ISSN
1110-0362
Abstract
Author(s): Nezhat Khanjani [sup.1], Sepideh Mirzaei [sup.1], Hamid Nasrolahi [sup.1], Seyed Hasan Hamedi [sup.1], Ahmad Mosalaei [sup.2], Shapour Omidvari [sup.3], Niloofar Ahmadloo [sup.1], Mansour Ansari [sup.3], Fatemeh Sobhani [sup.1], Mohammad [...]
Background This study aimed to investigate the sufficient ([greater than or equal to] 16) lymph node assessment in 449 patients with gastric adenocarcinoma and literature review. Methods Four hundred and forty-nine patients with pathologically confirmed locoregional invasive gastric adenocarcinoma from 2004 to 2013 were included. A standard surgical resection was performed for all the patients with (n = 16) or without (n = 433) neoadjuvant treatment. Results In this study, 301 men and 148 women with a median age of 58 (range 21-88) years were included. The median total numbers of examined lymph nodes were 9 (range 0-55). Ninety-five patients (21.2%) had adequate ([greater than or equal to] 16) lymph node examination, and 70 patients (15.6%) had no examined lymph nodes. In univariate analysis, total or near total gastrectomy (P < 0.001), advanced node stage (P 6 cm (P < 0.001), and the presence of perineural invasion (P = 0.039) were associated with more average number of examined lymph nodes. On multivariate analysis, node stage (P < 0.001) and type of surgery (P = 0.008) were independent predictive factors. Conclusion In this study, approximately one in five patients with gastric adenocarcinoma had sufficient lymph node assessment. More studies are suggested for identifying a true inadequate lymph node dissection from insufficient lymph node assessment.
Background This study aimed to investigate the sufficient ([greater than or equal to] 16) lymph node assessment in 449 patients with gastric adenocarcinoma and literature review. Methods Four hundred and forty-nine patients with pathologically confirmed locoregional invasive gastric adenocarcinoma from 2004 to 2013 were included. A standard surgical resection was performed for all the patients with (n = 16) or without (n = 433) neoadjuvant treatment. Results In this study, 301 men and 148 women with a median age of 58 (range 21-88) years were included. The median total numbers of examined lymph nodes were 9 (range 0-55). Ninety-five patients (21.2%) had adequate ([greater than or equal to] 16) lymph node examination, and 70 patients (15.6%) had no examined lymph nodes. In univariate analysis, total or near total gastrectomy (P < 0.001), advanced node stage (P 6 cm (P < 0.001), and the presence of perineural invasion (P = 0.039) were associated with more average number of examined lymph nodes. On multivariate analysis, node stage (P < 0.001) and type of surgery (P = 0.008) were independent predictive factors. Conclusion In this study, approximately one in five patients with gastric adenocarcinoma had sufficient lymph node assessment. More studies are suggested for identifying a true inadequate lymph node dissection from insufficient lymph node assessment.