부산대학교 도서관

Objective: Neonatal sepsis is an important cause of neonatal mortality and morbidity, especially in low birth-weight premature babies. This study aimed to examine the clinical and laboratory features of cases with culture-positive neonatal sepsis. Method: Medical records of 233 newborn infants with culture-positive sepsis among 4241 hospitalized patients between January 2013 and December 2017 were reviewed. Demographic and clinical data of these patients were retrospectively recorded. Results: The majority of patients was extremely and moderately preterm infants (39.1% vs. 11.6%). These patients had a history of invasive mechanical ventilation (74.2%) or central catheterization (26.9%). The mostly isolated pathogens (56.2%) were Gram-negative bacteria, especially Klebsiella pneumoniae in 67 (28.8%) cases. Post-hoc test showed a statistically significant difference in the incidence rates of leukopenia between patients infected with Gram-positive, Gram-negative bacteria and fungi (12.3%, 16.8% and 17.2%, respectively) (p=0.021). Patients who developed leukopenia (n=36, 15.5%) had a higher mortality rate compared to those with leukocytosis (n=50, 21.5%) (72.2% vs. 50%, p Conclusion: Prolonged parenteral nutrition is an important risk factor for mortality in low-birth weight newborns and those with sepsis. It is noteworthy that the mortality rate is higher in newborns with sepsis who developed leukopenia and neutropenia. Keywords: Newborn, microorganism, risk factors, sepsis, prognosis Amac: Neonatal sepsis yenidoganda, ozellikle de dusuk dogum agirlikli premature bebeklerde onemli bir mortalite ve morbidite nedenidir. Bu calismada kultur pozitif neonatal sepsisli hastalarin klinik ve laboratuvar ozelliklerinin arastirilmasi amaclandi. Yontem: Ocak 2013 ile Aralik 2017 tarihleri arasinda hastanemizde yatan 4241 hasta arasinda kultur pozitif sepsis tanisi alan 233 yenidogan bebegin tibbi kayitlari incelendi. Bu hastalarin demografik ve klinik verileri geriye donuk olarak kaydedildi. Bulgular: Hastalarin cogunlugunu ileri derecede ve orta derecede premature bebekler olusturmaktaydi (%39,1 vs. %11,6). Bunlarin %74,2'sinde invaziv mekanik ventilasyon, %26,9'unda santral kateterizasyon oykusu vardi. En cok izole edilen patojenler (%56,2) Gram-negatif bakteriler, ozellikle Klebsiella pneumoniae (n=67, %28,8) idi. Posthoc analizi Gram-pozitif ve Gram-negatif bakteriler ile mantarlar arasinda lokopeni yonunden istatistiksel olarak anlamli bir fark oldugunu (sirasiyla %12,3, %16,8 ve %17,2) gosterdi (p=0,021). Lokopeni gelisen hastalarda (n=36, %15,5) olum orani, lokositoz gelisen hastalara (n=50, %21,5) gore daha yuksekti (%72,2 vs. %50, p Anahtar kelimeler: Yenidogan, mikroorganizma, risk faktorleri, sepsis, prognoz
INTRODUCTION Neonatal sepsis is a clinical syndrome characterized by systemic symptoms and signs of infection in the first month of life, whether or not a specific microorganism was isolated in [...]