부산대학교 도서관

Introduction: Severe exacerbations associated with chronic obstructive pulmonary disease (COPD) that require hospitalization significantly contribute to morbidity and mortality. Definitions for exacerbations are very broad, and it is unclear whether there is one predominant underlying mechanism that leads to them. Functional respiratory imaging (FRI) with modeling provides detailed information about airway resistance, hyperinflation, and ventilation-perfusion (V/Q) mismatch during and following an acute exacerbation. Materials and methods: Forty-two patients with COPD participating in a multicenter study were assessed by FRI, pulmonary function tests, and self-reported outcome measures during an acute exacerbation and following resolution. Arterial blood gasses and lung function parameters were measured. Results: A significant correlation was found between alveolar-arterial gradient and image-based V/Q (iV/Q), suggesting that iV/Q represents V/Q mismatch during an exacerbation (p Conclusion: Recovery of an exacerbation is due to decreased (mainly distal) airway resistance (p Keywords: acute exacerbation, high-resolution computed tomography, functional respiratory imaging, ventilation-perfusion, airway resistance
Introduction Exacerbation frequency has been increasingly used as an endpoint in clinical trials for obstructive lung diseases such as asthma and COPD. While an exacerbating episode is, without doubt, clinically [...]