부산대학교 도서관

Cefaclor, a second-generation oral cephalosporin, is the most frequently prescribed cephalosporin in Korea. Studies, however, have yet to analyze the incidence of cefaclor-associated adverse drug reactions (ADRs), including hypersensitivity (HS), according to total national usage rates. This study aimed to investigate the incidence rates and clinical features of cefaclor ADRs reported to the Korean Adverse Event Reporting System (KAERS) and Health Insurance Review and Assessment Service (HIRA) database for the most recent 5 years. Reviewing the HIRA database, which contains information on all insurance claims, including prescribed medications and patient demographics, we identified the total number of individuals who had been prescribed cefaclor and other cephalosporins including 2.sup.nd generation without cefaclor and 3.sup.rd generation antibiotics from January 2014 to December 2018. Additionally, we retrospectively analyzed all ADRs reported to the KAERS for these drugs over the same study period. Incidence rates for ADRs, HS, and anaphylaxis to cefaclor were 1.92/10,000 persons, 1.17/10,000 persons, and 0.38/10,000 persons, respectively, lower than those to other 2.sup.nd and 3.sup.rd cephalosporins. Among all ADRs, HS (60.9% vs. 43.6% vs. 44.8%, P
Author(s): Hyo-In Rhyou 1,2, Young-Hee Nam 1,2, Su-Chin Kim 3, Go-Eun Doo 4, Chae-Yeon Ha 4, Hee-Joo Nam 1,2, Sung-Dae Woo 4,5, Youngsoo Lee 4,5, Jae-Hyuk Jang 4,5, Hyun-Young Lee [...]