부산대학교 도서관

A DNA sequence consisting of (GGAAT)(sub n) repeats was isolated from a library constructed from randomly sheared and reassociated DNA. In situ hybridization analysis localized this repetitive sequence to the centromeric region, while hybridization studies involving diverse species showed that the sequence is highly conserved. Due to the presence of G-A base pairs, the conserved sequence displayed high thermal stability, while hyperchromicity studies indicated that the sequence has unusual hydrogen bonding properties. The results suggest that this sequence mayrepresent a functional code which has been conserved for more than one billion years.