학술논문
Heart failure and the risk of left atrial thrombus formation in patients with atrial fibrillation or atrial flutter
Document Type
Clinical report
Author
Wybraniec, Maciej T.; Mizia‐Szubryt, Magdalena; Cichoń, Małgorzata; Wrona‐Kolasa, Karolina; Kapłon‐Cieślicka, Agnieszka; Gawałko, Monika; Budnik, Monika; Uziębło‐Życzkowska, Beata; Krzesiński, Paweł; Starzyk, Katarzyna; Gorczyca‐Głowacka, Iwona; Daniłowicz‐Szymanowicz, Ludmiła; Kaufmann, Damian; Wójcik, Maciej; Błaszczyk, Robert; Hiczkiewicz, Jarosław; Łojewska, Katarzyna; Kosmalska, Katarzyna; Fijałkowski, Marcin; Szymańska, Anna; Wiktorska, Anna; Haberka, Maciej; Kucio, Michał; Michalski, Błażej; Kupczyńska, Karolina; Tomaszuk‐Kazberuk, Anna; Wilk‐Śledziewska, Katarzyna; Wachnicka‐Truty, Renata; Koziński, Marek; Burchardt, Paweł; Mizia‐Stec, Katarzyna
Source
ESC Heart Failure. December 2022, Vol. 9 Issue 6, p4064, 13 p.
Subject
Language
English
Abstract
Introduction The steadily growing coexistence of heart failure (HF) and atrial fibrillation (AF) is associated with significantly increased in‐hospital mortality.[sup.1] The clinical significance of HF in AF patients consists in [...]
: Aims: The aim of the study was to evaluate the prevalence of left atrial thrombus (LAT) on transoesophageal echocardiography (TOE) in patients with atrial fibrillation or atrial flutter (AF/AFl) with reference to the presence of heart failure (HF) and its subtypes. Methods and results: The research is a sub‐study of the multicentre, prospective, observational Left Atrial Thrombus on Transoesophageal Echocardiography (LATTEE) registry, which comprised 3109 consecutive patients with AF/AFl undergoing TOE prior to direct current cardioversion or catheter ablation. TOE parameters, including presence of LAT, were compared between patients with and without HF and across different subtypes of HF, including HF with preserved (HFpEF), mid‐range (HFmrEF), and reduced ejection fraction (HFrEF). HF was diagnosed in 1336 patients (43%). HF patients had higher prevalence of LAT than non‐HF patients (12.8% vs. 4.4%; P < 0.001). LAT presence increased with more advanced type of systolic dysfunction (HFpEF vs. HFmrEF vs. HFrEF: 7.4% vs. 10.5% vs. 20.3%; P < 0.001). Univariate analysis revealed that HFrEF (odds ratio [OR] 4.13; 95% confidence interval [95% CI]: 3.13–5.46), but not HFmrEF or HFpEF, was associated with the presence of LAT. Multivariable logistic regression indicated that lower left ventricular ejection fraction (OR per 1%: 0.94; 95% CI 0.93–0.95) was an independent predictor of LAT formation. Receiver operator characteristic analysis showed LVEF ≤48% adequately predicted increased risk of LAT presence (area under the curve [AUC] 0.74; P < 0.0001). Conclusion: The diagnosis of HFrEF, but neither HFmrEF nor HFpEF, confers a considerable risk of LAT presence despite widespread utilization of adequate anticoagulation.
: Aims: The aim of the study was to evaluate the prevalence of left atrial thrombus (LAT) on transoesophageal echocardiography (TOE) in patients with atrial fibrillation or atrial flutter (AF/AFl) with reference to the presence of heart failure (HF) and its subtypes. Methods and results: The research is a sub‐study of the multicentre, prospective, observational Left Atrial Thrombus on Transoesophageal Echocardiography (LATTEE) registry, which comprised 3109 consecutive patients with AF/AFl undergoing TOE prior to direct current cardioversion or catheter ablation. TOE parameters, including presence of LAT, were compared between patients with and without HF and across different subtypes of HF, including HF with preserved (HFpEF), mid‐range (HFmrEF), and reduced ejection fraction (HFrEF). HF was diagnosed in 1336 patients (43%). HF patients had higher prevalence of LAT than non‐HF patients (12.8% vs. 4.4%; P < 0.001). LAT presence increased with more advanced type of systolic dysfunction (HFpEF vs. HFmrEF vs. HFrEF: 7.4% vs. 10.5% vs. 20.3%; P < 0.001). Univariate analysis revealed that HFrEF (odds ratio [OR] 4.13; 95% confidence interval [95% CI]: 3.13–5.46), but not HFmrEF or HFpEF, was associated with the presence of LAT. Multivariable logistic regression indicated that lower left ventricular ejection fraction (OR per 1%: 0.94; 95% CI 0.93–0.95) was an independent predictor of LAT formation. Receiver operator characteristic analysis showed LVEF ≤48% adequately predicted increased risk of LAT presence (area under the curve [AUC] 0.74; P < 0.0001). Conclusion: The diagnosis of HFrEF, but neither HFmrEF nor HFpEF, confers a considerable risk of LAT presence despite widespread utilization of adequate anticoagulation.