부산대학교 도서관

Introduction: The pandemic of obesity is strongly related to increase of chronic kidney disease (CKD) prevalence. The currently recommended CKD epidemiology collaboration (CKD EPI) equation has several serious limitations, particularly in obese subjects who have high body surface area (BSA). The aim of our study was to analyze differences in the prevalence of CKD between CKD EPI and de-indexed equations where individual BSA was used. Methods: In a total of 2,058 subjects (random sample from a general rural population, 29.65% obese), BSA was estimated using DuBois and DuBois and Moesteller equations and included into the de-indexed equations (CKD DBi, CKD Mi). CKD was classified according to the KDIGO guidelines, and glomerular hyperfiltration (GHF) was defined as 95th percentile, according to the gender and age decade. Results: In obese subjects, prevalence of CKD was significantly higher with CKD EPI than with CKD DBi and CKD Mi equations (9.5%, 6.1%, 5.3%, respectively; p < 0.001), while prevalence of GHF was significantly lower (3.8%, 12.3%, 12.8%, respectively; p < 0.001). Opposite results were observed in subjects with a body mass index Keywords: CKD EPI, Chronic kidney disease, Estimated glomerular filtration rate, Glomerular hyperfiltration, Obesity
Author(s): Marija Domislovic [a]; Viktor Domislovic [b]; Mirjana Fucek [c]; Ana Jelakovic [a]; Lana Gellineo [a]; Zivka Dika [a,d]; Bojan Jelakovic [a,d] Introduction Chronic kidney disease (CKD) is one of [...]