부산대학교 도서관

Purpose: Diagnosing heparin-induced thrombocytopenia, a potentially catastrophic immune-mediated disorder, continues to pose significant challenges for clinicians, as both clinical and laboratory tools lack specificity. There is mounting evidence supporting a positive correlation between definitive heparin-induced thrombocytopenia and optical density (OD) positivity from the widely available anti-platelet factor 4 enzyme-linked immunosorbent assays (PF4 ELISAs). However, the clinical features distinguishing these patients remain poorly understood. Patients and methods: To better characterize this group, we conducted a case-controlled, retrospective chart review of patients from two large, urban academic institutions who underwent a PF4 ELISA at a central laboratory. Associations between OD and 18 clinical characteristics were calculated using the Fisher's exact test for categorical variables and Wilcoxon rank-sum test for continuous variables. Results: In total, 184 negative patients (OD 0.7), including 74 low-positive patients (0.7< OD 1.4) were identified. Several clinical variables were significantly different in the negative group compared with the positive group, including hospital day (P Conclusion: These data indicate that those with OD >1.4 form a distinct clinical group and support the clinical utility of the 4T score. Keywords: heparin-induced thrombocytopenia, platelet factor 4 ELISA, thrombocytopenia, HIT, heparin
Introduction Heparin-induced thrombocytopenia (HIT) is a potentially severe, adverse reaction to the widely used anticoagulant heparin. Although heparin is a well-established effective anticoagulant, in the presence of heparin, auto IgG [...]