학술논문
Genotype frequency and F .sub.ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations
Document Type
Report
Author abstract
Author abstract
Author
Lan, Qing; Shen, Min; Garcia-Rossi, Dino; Chanock, Stephen; Zheng, Tongzhang; Berndt, Sonja I.; Puri, Vinita; Li, Guilan; He, Xingzhou; Welch, Robert; Zahm, Shelia H.; Zhang, Luoping; Zhang, Yawei; Smith, Martyn; Wang, Sophia S.; Chiu, Brian C.-H.; Linet, Martha; Hayes, Richard; Rothman, Nathaniel; Yeager, Meredith
Source
Immunogenetics. Nov, 2007, Vol. 59 Issue 11, p839, 14 p.
Subject
Language
English
ISSN
0093-7711
Abstract
Selection and genetic drift can create genetic differences between populations. Cytokines and chemokines play an important role in both hematopoietic development and the inflammatory response. We compared the genotype frequencies of 45 SNPs in 30 cytokine and chemokine genes in two healthy Chinese populations and one Caucasian population. Several SNPs in IL4 had substantial genetic differentiation between the Chinese and Caucasian populations (F .sub.ST ~0.40), and displayed a strikingly different haplotype distribution. To further characterize common genetic variation in worldwide populations at the IL4 locus, we genotyped 9 SNPs at the IL4 gene in the Human Diversity Panel's (N=1056) individuals from 52 world geographic regions. We observed low haplotype diversity, yet strikingly different haplotype frequencies between non-African populations, which may indicate different selective pressures on the IL4 gene in different parts of the world. SNPs in CSF2, IL6, IL10, CTLA4, and CX3CR1 showed moderate genetic differentiation between the Chinese and Caucasian populations (0.15