학술논문
An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation
Document Type
Academic Journal
Author
Source
Cell. April 19, 2002, Vol. 109 Issue 2, p169, 12 p.
Subject
Language
ISSN
0092-8674
Abstract
Research shows that induction of the Ets domain repressor, METS, during macrophage differentiation, arrests the terminal cell cycle by repressing transcription of the cell cycle control genes. Data indicate that METS selectively represses Ets target genes mediateing Ras-dependent proliferation witthout affecting the genes involved in the Ras-dependent differentiation.