부산대학교 도서관

Hyperglycemia in diabetes mellitus (DM) is associated with increased production of reactive oxygen species (ROS) which rapidly interact with proteins, lipids, and carbohydrates and may cause renal damage. Glutathione-S-Transferase (GST) is primarily involved in the neutralization of harmful exogenous or endogenous compounds by enzymatic conjugation with the scavenger peptide glutathione (GSH). Hence, it is involved in combating oxidative stress. The present study was aimed to assess the activity of GST, reduced glutathione (GSH) levels and their correlation in patients with Type 2 diabetes mellitus with and without nephropathy. This study comprised of 300 participants divided into three groups of 100 each: Type 2 diabetic patients (T2DM) without nephropathy, Type 2 diabetic patients with nephropathy (T2DM-CKD) and healthy controls (HC). Plasma GST activity and blood GSH levels were estimated spectrophotometrically. Highest GST activity was observed in DM (8.50 [+ or -] 0.55) which was significantly higher as compared to DM-CKD (7.39 [+ or -] 0.50; P
P065 Mohini Sharma (1), S Gupta (1), K Singh (1), M Mehndiratta (1), OP Kalra (2), R Shukla (1), JK Gambhir (1) Departments of Biochemistry (1) and Medicine (2), University [...]