학술논문
Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine
Document Type
Report
Author
Beharier, Ofer; Mayo, Romina Plitman; Raz, Tal; Sacks, Kira Nahum; Schreiber, Letizia; Suissa-Cohen, Yael; Chen, Rony; Gomez-Tolub, Rachel; Hadar, Eran; Gabbay- Benziv, Rinat; Moshkovich, Yuval Jaffe; Biron-Shental, Tal; Shechter-Maor, Gil; Farladansky-Gershnabel, Sivan; Sela, Hen Yitzhak; Benyamini-Raischer, Hedi; Sela, Nitzan D.; Goldman-Wohl, Debra; Shulman, Ziv; Many, Ariel; Barr, Haim; Yagel, Simcha; Neeman, Michal; Kovo, Michal
Source
Journal of Clinical Investigation. July 1, 2021, Vol. 131 Issue 13
Subject
Language
English
ISSN
0021-9738
Abstract
BACKGROUND. The significant risks posed to mothers and fetuses by COVID-19 in pregnancy have sparked a worldwide debate surrounding the pros and cons of antenatal SARS-CoV-2 inoculation, as we lack sufficient evidence regarding vaccine effectiveness in pregnant women and their offspring. We aimed to provide substantial evidence for the effect of the BNT162b2 mRNA vaccine versus native infection on maternal humoral, as well as transplacentally acquired fetal immune response, potentially providing newborn protection. METHODS. A multicenter study where parturients presenting for delivery were recruited at 8 medical centers across Israel and assigned to 3 study groups: vaccinated (n = 86); PCR-confirmed SARS-CoV-2 infected during pregnancy (n = 65), and unvaccinated noninfected controls (n = 62). Maternal and fetal blood samples were collected from parturients prior to delivery and from the umbilical cord following delivery, respectively. Sera IgG and IgM titers were measured using the Milliplex MAP SARS-CoV-2 Antigen Panel (for S1, S2, RBD, and N). RESULTS. The BNT162b2 mRNA vaccine elicits strong maternal humoral IgG response (anti-S and RBD) that crosses the placenta barrier and approaches maternal titers in the fetus within 15 days following the first dose. Maternal to neonatal antiCOVID-19 antibodies ratio did not differ when comparing sensitization (vaccine vs. infection). IgG transfer ratio at birth was significantly lower for third-trimester as compared with second trimester infection. Lastly, fetal IgM response was detected in 5 neonates, all in the infected group. CONCLUSION. Antenatal BNT162b2 mRNA vaccination induces a robust maternal humoral response that effectively transfers to the fetus, supporting the role of vaccination during pregnancy. FUNDING. Israel Science Foundation and the Weizmann Institute Fondazione Henry Krenter.
Introduction The worldwide pandemic of COVID-19 continues to spread, with substantial morbidity and mortality. To date, more than 80,000 pregnant women have been infected in the U.S. alone, and the [...]
Introduction The worldwide pandemic of COVID-19 continues to spread, with substantial morbidity and mortality. To date, more than 80,000 pregnant women have been infected in the U.S. alone, and the [...]