학술논문
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
Document Type
Report
Author
Martín-Peláez, Sandra; Serra-Majem, Lluis; Cano-Ibáñez, Naomi; Martínez-González, Miguel Ángel; Salas-Salvadó, Jordi; Corella, Dolores; Lassale, Camille; Martínez, Jose Alfredo; Alonso-Gómez, Ángel M.; Wärnberg, Julia; Vioque, Jesús; Romaguera, Dora; López-Miranda, José; Estruch, Ramón; Tinahones, Francisco J.; Lapetra, José; Fernández-Aranda, Fernando; Bueno-Cavanillas, Aurora; Tur, Josep A.; Martín, Vicente; Pintó, Xavier; Delgado-Rodríguez, Miguel; Matía, Pilar; Vidal, Josep; Vázquez, Clotilde; Daimiel, Lidia; Ros, Emili; Toledo, Estefanía; Nishi, Stephanie K.; Sorli, Jose V.; Malcampo, Mireia; Zulet, M. Ángeles; Moreno-Rodríguez, Anaí; Cueto-Galán, Raquel; Vivancos-Aparicio, Diego; Colom, Antoni; García-Ríos, Antonio; Casas, Rosa; Bernal-López, M Rosa; Santos-Lozano, Jose Manuel; Vázquez, Zenaida; Gómez-Martínez, Carlos; Ortega-Azorín, Carolina; del Val, Jose Luís; Abete, Itziar; Goikoetxea-Bahon, Amaia; Pascual, Elena; Becerra-Tomás, Nerea; Chillarón, Juan J.; Sánchez-Villegas, Almudena
Source
PLoS ONE. April 13, 2022, Vol. 17 Issue 4, e0265079
Subject
Language
English
ISSN
1932-6203
Abstract
Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870).
Author(s): Sandra Martín-Peláez 1,2,*, Lluis Serra-Majem 3,4, Naomi Cano-Ibáñez 1,2,5, Miguel Ángel Martínez-González 3,6,7, Jordi Salas-Salvadó 3,8,9,10, Dolores Corella 3,11, Camille Lassale 3,12, Jose Alfredo Martínez 3,13,14,Ángel M. Alonso-Gómez 3,15, [...]
Author(s): Sandra Martín-Peláez 1,2,*, Lluis Serra-Majem 3,4, Naomi Cano-Ibáñez 1,2,5, Miguel Ángel Martínez-González 3,6,7, Jordi Salas-Salvadó 3,8,9,10, Dolores Corella 3,11, Camille Lassale 3,12, Jose Alfredo Martínez 3,13,14,Ángel M. Alonso-Gómez 3,15, [...]