학술논문
Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: Effect of alkyl chain length
Document Type
Report
Author
Source
Bioorganic & Medicinal Chemistry Letters. July 15, 2008, Vol. 18 Issue 14, p4249, 4 p.
Subject
Language
English
ISSN
0960-894X
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bmcl.2008.02.020 Byline: Shuichi Mori (a), Shinya Miyake (a), Takayoshi Kobe (a), Takaaki Nakaya (b), Stephen D. Fuller (c), Nobuo Kato (a), Kunihiro Kaihatsu (a) Keywords: Epigallocatechin gallate; Influenza virus; Lipase-catalyzed esterification; Antivirus agent Abstract: A series of fatty acid monoester derivatives of (-)-epigallocatechin-3-O-gallate (EGCG) were prepared by one-pot lipase-catalyzed transesterification. The introduction of long alkyl chains enhanced anti-influenza A/PR8/34 (H1N1) virus activity up to 24-fold relative to native EGCG. Author Affiliation: (a) The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan (b) Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan (c) Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK Article History: Received 20 September 2007; Revised 1 February 2008; Accepted 7 February 2008