학술논문
Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine
Document Type
Report
Author
Source
Acta Crystallographica Section F. July, 2008, Vol. 64 Issue 7, p577, 7 p.
Subject
Language
English
ISSN
1744-3091
Abstract
To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1107/S174430910801556X Byline: David B. Langley, Daniel M. Trambaiolo, Anthony P. Duff, David M. Dooley, Hans C. Freeman, J. Mitchell Guss Keywords: amine oxidases; AGAO; benzylhydrazine; tranylcypromine; topaquinone; copper Abstract: Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 A resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation. Author Affiliation: (a)School of Molecular and Microbial Biosciences, University of Sydney, Australia (b)Department of Chemistry and Biochemistry, Montana State University, USA Article History: Received 3 April 2008, accepted 23 May 2008 Article note: J. Mitchell Guss, e-mail: m.guss@usyd.edu.au