학술논문
Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS
acute respiratory distress syndrome
acute respiratory distress syndrome
Document Type
Report
Author
Morales-Quinteros, Luis; Neto, Ary Serpa; Artigas, Antonio; Blanch, Lluis; Botta, Michela; Kaufman, David A.; Schultz, Marcus J.; Tsonas, Anissa M.; Paulus, Frederique; Bos, Lieuwe D.; Serpa Neto, Ary; Algera, A. G.; Boers, L. S.; Bos, L. D. J.; Pillay, J.; Dongelmans, D. A.; Hollmann, M. W.; Horn, J.; Vlaar, A. P.; van Akkeren, J. P.; Algoe, C. K.; van Amstel, R. B.; Baur, O. L.; van de Berg, P.; van den Berg, A. E.; Bergmans, D. C. J. J.; van den Bersselaar, D. I.; Bertens, F. A.; Bindels, A. J. G. H.; de Boer, M. M.; Boer, S. den; Bogerd, M.; Breel, J. S.; de Bruin, H.; de Bruin, S.; Bruna, C. L.; Buiteman-Kruizinga, L. A.; Cremer, O.; Determann, R. M.; Dieperink, W.; Franke, H. S.; Galek-Aldridge, M. S.; de Graaff, M. J.; Hagens, L. A.; Haringman, J. J.; van der Heide, S. T.; van der Heiden, P. L. J.; Heijnen, N. F. L.; Hiel, S. J. P.; Hoeijmakers, L. L.; Hol, L.; Hoogendoorn, M. E.; van der Horst, R.; Ie, E. L. K.; Ivanov, D.; Juffermans, N. P.; Kho, E.; de Klerk, E. S.; Gemert, A. W. M. M. Koopman-van; Koopmans, M.; Kucukcelebi, S.; Kuiper, M. A.; de Lange, D. W.; van Mourik, N.; Nijbroek, S. G.; Onrust, M.; Oostdijk, E. A. N.; Pennartz, C. J.; Pisani, L.; Purmer, I. M.; Rettig, T. C. D.; Roozeman, J. P.; Schuijt, M. T. U.; Sleeswijk, M. E.; Smit, M. R.; Spronk, P. E.; Stilma, W.; Strang, A. C.; Tuinman, P. R.; Valk, C. M. A.; Veen-Schra, F. L.; Veldhuis, L. I.; van Velzen, P.; van der Ven, W. H.; Vlaar, A. P. J.; van Vliet, P.; van der Voort, P. H. J.; van Welie, L.; Wesselink, H. J. F. T.; van der Wier-Lubbers, H. H.; van Wijk, B.; Winters, T.; Wong, W. Y.; van Zanten, A. R. H.
Source
Critical Care. May 17, 2021, Vol. 25 Issue 1
Subject
Language
English
ISSN
1364-8535
Abstract
Author(s): Luis Morales-Quinteros[sup.1,2,3] , Ary Serpa Neto[sup.4,5,6,7] , Antonio Artigas[sup.2,3,8,9] , Lluis Blanch[sup.2,3,8,9] , Michela Botta[sup.4] , David A. Kaufman[sup.10] , Marcus J. Schultz[sup.4,11,12] , Anissa M. Tsonas[sup.4] , Frederique [...]
Background Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS. Methods Secondary analysis from the PRoVENT-COVID study. The PRoVENT-COVID is a national, multicenter, retrospective observational study done at 22 intensive care units in the Netherlands. Consecutive patients aged at least 18 years were eligible for participation if they had received invasive ventilation for COVID-19 at a participating ICU during the first month of the national outbreak in the Netherlands. The aim was to quantify the dynamics and determine the prognostic value of surrogate markers of wasted ventilation in patients with COVID-19-related ARDS. Results A total of 927 consecutive patients admitted with COVID-19-related ARDS were included in this study. Estimations of wasted ventilation such as the estimated dead space fraction (by Harris-Benedict and direct method) and ventilatory ratio were significantly higher in non-survivors than survivors at baseline and during the following days of mechanical ventilation (p < 0.001). The end-tidal-to-arterial PCO.sub.2 ratio was lower in non-survivors than in survivors (p < 0.001). As ARDS severity increased, mortality increased with successive tertiles of dead space fraction by Harris-Benedict and by direct estimation, and with an increase in the VR. The same trend was observed with decreased levels in the tertiles for the end-tidal-to-arterial PCO.sub.2 ratio. After adjustment for a base risk model that included chronic comorbidities and ventilation- and oxygenation-parameters, none of the dead space estimates measured at the start of ventilation or the following days were significantly associated with 28-day mortality. Conclusions There is significant impairment of ventilation in the early course of COVID-19-related ARDS but quantification of this impairment does not add prognostic information when added to a baseline risk model. Trial registration: ISRCTN04346342. Registered 15 April 2020. Retrospectively registered. Keywords: Acute respiratory distress syndrome, ARDS, Respiratory dead space, Dead space, Ventilatory ratio, COVID-19, Mortality, Prognostication
Background Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS. Methods Secondary analysis from the PRoVENT-COVID study. The PRoVENT-COVID is a national, multicenter, retrospective observational study done at 22 intensive care units in the Netherlands. Consecutive patients aged at least 18 years were eligible for participation if they had received invasive ventilation for COVID-19 at a participating ICU during the first month of the national outbreak in the Netherlands. The aim was to quantify the dynamics and determine the prognostic value of surrogate markers of wasted ventilation in patients with COVID-19-related ARDS. Results A total of 927 consecutive patients admitted with COVID-19-related ARDS were included in this study. Estimations of wasted ventilation such as the estimated dead space fraction (by Harris-Benedict and direct method) and ventilatory ratio were significantly higher in non-survivors than survivors at baseline and during the following days of mechanical ventilation (p < 0.001). The end-tidal-to-arterial PCO.sub.2 ratio was lower in non-survivors than in survivors (p < 0.001). As ARDS severity increased, mortality increased with successive tertiles of dead space fraction by Harris-Benedict and by direct estimation, and with an increase in the VR. The same trend was observed with decreased levels in the tertiles for the end-tidal-to-arterial PCO.sub.2 ratio. After adjustment for a base risk model that included chronic comorbidities and ventilation- and oxygenation-parameters, none of the dead space estimates measured at the start of ventilation or the following days were significantly associated with 28-day mortality. Conclusions There is significant impairment of ventilation in the early course of COVID-19-related ARDS but quantification of this impairment does not add prognostic information when added to a baseline risk model. Trial registration: ISRCTN04346342. Registered 15 April 2020. Retrospectively registered. Keywords: Acute respiratory distress syndrome, ARDS, Respiratory dead space, Dead space, Ventilatory ratio, COVID-19, Mortality, Prognostication