학술논문
Cloning, characterization, and functional expression of a CNP receptor regulating CFTR in the shark rectal gland
C-type natriuretic peptide; cystic fibrosis transmembrane conductance regulator
C-type natriuretic peptide; cystic fibrosis transmembrane conductance regulator
Document Type
Academic Journal
Source
American Journal of Physiology (Consolidated). Feb 1999, Vol. 276 Issue 2, pC442, 8 p.
Subject
Language
ISSN
0002-9513
Abstract
The first evidence for activation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels by a cloned ancestral C-type natriuretic peptide (CNP) receptor is presented. Such evidence was gathered from results of the cloning, characterization and functional expression of a CNP receptor regulating CFTR in the shark rectal gland. Results also identify the specific natriuretic peptide receptor responsible for Cl- secretion in the shark rectal gland.