학술논문
Sclerostin is a possible candidate marker of arterial stiffness: results from a cohort study in Catania
Document Type
Academic Journal
Author
Source
Molecular Medicine Reports. May 2017, Vol. 15 Issue 5, p3420, 5 p.
Subject
Language
English
ISSN
1791-2997
Abstract
Introduction Osteoporosis and cardiovascular disease (CVD) are worldwide public health issues, which represent major factors for mortality and morbidity in elderly populations. Although degenerative changes in bone and atherosclerosis (the [...]
Osteoporosis and cardiovascular disease are worldwide public health issues. Recent evidence indicates a possible role of the canonical Wnt/[beta]-catenin signalling pathway as a common mediator between these two diseases. The aim of the present study was to investigate the relationship between serum concentrations of sclerostin and Dkk1, two extracellular inhibitors of Wnt/[beta]-catenin signalling, with carotid intima-media thickness (CIMT) and with arterial stiffness, evaluated by measuring the pulse wave velocity (PWV) in an ambulatory population of adults. To this aim, 67 subjects were recruited in the 'Atherosclerosis and osteoporosis: identification of common pathogenetic factors' investigation. Serum sclerostin levels correlated positively with CIMT (r=0.314, p=0.03) and inversely with the augmentation index, a marker of arterial stiffness (r=-0.286, p Key words: sclerostin, Dkk1, CIMT, augmentation index, pulse wave velocity
Osteoporosis and cardiovascular disease are worldwide public health issues. Recent evidence indicates a possible role of the canonical Wnt/[beta]-catenin signalling pathway as a common mediator between these two diseases. The aim of the present study was to investigate the relationship between serum concentrations of sclerostin and Dkk1, two extracellular inhibitors of Wnt/[beta]-catenin signalling, with carotid intima-media thickness (CIMT) and with arterial stiffness, evaluated by measuring the pulse wave velocity (PWV) in an ambulatory population of adults. To this aim, 67 subjects were recruited in the 'Atherosclerosis and osteoporosis: identification of common pathogenetic factors' investigation. Serum sclerostin levels correlated positively with CIMT (r=0.314, p=0.03) and inversely with the augmentation index, a marker of arterial stiffness (r=-0.286, p Key words: sclerostin, Dkk1, CIMT, augmentation index, pulse wave velocity