학술논문
Association of Tumor Cell Metabolic Subtype and Immune Response With the Clinical Course of Hepatocellular Carcinoma
Original Article
Original Article
Document Type
Academic Journal
Author
Source
The Oncologist. November 2023, Vol. 28 Issue 11, pe1031, 12 p.
Subject
Language
English
ISSN
1083-7159
Abstract
Implications for Practice Hepatocellular carcinoma (HCC) is one of the most common malignancies. The Barcelona Clinic Liver Cancer (BCLC) staging is used widely, but its value is limited. The molecular [...]
Aim: Tumor metabolism plays an important role in tumorigenesis and tumor progression. This study evaluated the potential association of tumor cell metabolism and immune cell tumor infiltration with the clinical course of hepatocellular carcinoma (HCC). Methods: Gene-wise normalization and principal component analysis were performed to evaluate the metabolic system. A tumor microenvironment score system of tumor immune cell infiltration was constructed to evaluate its association with metabolic subtypes. Finally, we analyzed the impact of metabolism and immune cell infiltration on the clinical course of HCC. Results: A total of 673 HCC patients were categorized into cholesterogenic (25.3%), glycolytic (14.6%), mixed (10.4%), and quiescent (49.8%) types based on glycolysis and cholesterol biosynthesis gene expression. The subgroups including the glycolytic genotyping expression (glycolytic and mixed types) showed a higher mortality rate. The glycolytic, cholesterogenic, and mixed types were positively correlated with M0 macrophage, resting mast cell, and naive B-cell infiltration (P = .013, P = .019, and P = .006, respectively). In TCGA database, high [CD8.sup.+] T cell and low M0 macrophage infiltration were associated with prolonged overall survival (OS, P = .0017 and P < .0001, respectively). Furthermore, in glycolytic and mixed types, patients with high M0 macrophage infiltration had a shorter OS (P = .03 and P = .013, respectively), and in quiescent type, patients with low naive B-cell infiltration had a longer OS (P = .007). Conclusions: Tumor metabolism plays a prognostic role and correlates with immune cell infiltration in HCC. M0 macrophage and [CD8.sup.+] T cell appear to be promising prognostic biomarker for HCC. Finally, M0 macrophages may represent a useful immunotherapeutic target in patients with HCC. Key words: hepatocellular carcinoma; metabolic reprogramming; immune microenvironment; programmed cell death-Ligand 1(PD-L1); macrophage.
Aim: Tumor metabolism plays an important role in tumorigenesis and tumor progression. This study evaluated the potential association of tumor cell metabolism and immune cell tumor infiltration with the clinical course of hepatocellular carcinoma (HCC). Methods: Gene-wise normalization and principal component analysis were performed to evaluate the metabolic system. A tumor microenvironment score system of tumor immune cell infiltration was constructed to evaluate its association with metabolic subtypes. Finally, we analyzed the impact of metabolism and immune cell infiltration on the clinical course of HCC. Results: A total of 673 HCC patients were categorized into cholesterogenic (25.3%), glycolytic (14.6%), mixed (10.4%), and quiescent (49.8%) types based on glycolysis and cholesterol biosynthesis gene expression. The subgroups including the glycolytic genotyping expression (glycolytic and mixed types) showed a higher mortality rate. The glycolytic, cholesterogenic, and mixed types were positively correlated with M0 macrophage, resting mast cell, and naive B-cell infiltration (P = .013, P = .019, and P = .006, respectively). In TCGA database, high [CD8.sup.+] T cell and low M0 macrophage infiltration were associated with prolonged overall survival (OS, P = .0017 and P < .0001, respectively). Furthermore, in glycolytic and mixed types, patients with high M0 macrophage infiltration had a shorter OS (P = .03 and P = .013, respectively), and in quiescent type, patients with low naive B-cell infiltration had a longer OS (P = .007). Conclusions: Tumor metabolism plays a prognostic role and correlates with immune cell infiltration in HCC. M0 macrophage and [CD8.sup.+] T cell appear to be promising prognostic biomarker for HCC. Finally, M0 macrophages may represent a useful immunotherapeutic target in patients with HCC. Key words: hepatocellular carcinoma; metabolic reprogramming; immune microenvironment; programmed cell death-Ligand 1(PD-L1); macrophage.