부산대학교 도서관

Despite the fact that Alzheimer's disease (AD) is the most common form of dementia, its underlying pathogenesis has not yet fully known. As an intricate and multifactorial disease, finding a potential therapy intercepting its pathological process is still out of reach. With an increase in evidence of the success of gut microbiota modulation as a therapy to other diseases, one should consider the same possibility in AD. Therefore, this literature review focuses on exploring the possibility of dietary intervention as an innovative therapy for AD by modulating the gut microbiota composition based on recent researches. The method used to assemble this literature review is by performing a comprehensive literature search with corresponding keywords. The result shows that Mediterranean dietary intervention, characterized by the high intake of omega-3 polyunsaturated fatty acids, antioxidant nutrients, and vitamins, has shown to be beneficial for brain functions development which targets the gut-brain axis. However, a higher level of evidence-based research is still needed to confirm further the findings in hope for a future implementation of this new insight as a therapy for AD and to unfold the gut microbiota role in it. Keywords: 'Alzheimer Disease', 'Gut Microbiota', 'Gut-brain axis' and 'Mediterranean Diet'.
Introduction Alzheimer's disease (AD) prevalence accounts for 50-75% of all forms of dementia, making it the most common form worldwide. (1) In April 2016, the World Health Organization (WHO) reported [...]