부산대학교 도서관

Introduction In mammals, the anterior pituitary gland is responsible for the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), two critical hormones (gonadotrophins) involved in the regulation of gonadal [...]
Follicle-stimulating hormone, both naturally synthesized and as commercial preparations, exists as different isoforms. Variation in the process of glycosylation, particularly in the number of terminal sialic-acid residues, gives rise to isoforms of varying acidic profiles with differences in half-life and bioactivity. Based on the known follicle- stimulating hormone isoform variation across the reproductive cycle, it is possible that the follicle-stimulating hormone isoform profile used in controlled ovarian stimulation may impact follicular recruitment and clinical treatment outcomes. In light of the uncertainty regarding the clinical relevance of follicle stimulating hormone isoforms in fertility treatment, published studies exploring this topic are reviewed. Keywords: follicle-stimulating hormone, isoform, gonadotrophin, heterogeneity