학술논문
Zyxin is upregulated in the nucleus by thymosin [beta]4 in SiHa cells
Document Type
Academic Journal
Source
Experimental Cell Research. Oct 15, 2006, Vol. 312 Issue 17, p3425, 7 p.
Subject
Language
English
ISSN
0014-4827
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.yexcr.2006.07.021 Byline: Hye-Sung Moon, Sharona Even-Ram, Hynda K. Kleinman, Hee-Jae Cha Keywords: Actin; Thymosin [beta]4; Migration; Zyxin; Focal adhesions; Nucleus Abstract: Thymosin [beta]4 is a 43-amino acid actin-binding protein that promotes cell migration and is important in angiogenesis, wound healing, and tumor metastasis. We searched for genes upregulated by thymosin [beta]4 and identified zyxin as increased in SiHa cells in the presence of exogenously added thymosin [beta]4 and when thymosin [beta]4 is overexpressed using adenoviral vectors. Both zyxin and thymosin [beta]4 show increased localization in the nucleus. We conclude that thymosin [beta]4 may exert some of its migration promoting activity via increased zyxin expression. Author Affiliation: National Institute of Dental and Craniofacial Research, NIH, 30 Convent Dr. MSC 4370, Bethesda, MD 20892-4370, USA Article History: Received 29 November 2005; Revised 17 July 2006; Accepted 18 July 2006