학술논문
Head-to-head comparison of ultrasound and .sup.99mTc-glucosamine SPECT/CT imaging of patients with rheumatoid arthritis: a single center prospective study
Research
Research
Document Type
Clinical report
Author
Source
The Egyptian Journal of Radiology and Nuclear Medicine. December 2023, Vol. 54 Issue 1
Subject
Language
English
ISSN
0378-603X
Abstract
Author(s): Osayande Evbuomwan [sup.1], Gerrit Engelbrecht [sup.1], Cathryn Driver [sup.2], Joseph Sempa [sup.3], Barend Jansen van Rensburg [sup.4], Mathys Labuschagne [sup.5], Je'nine Horn-Lodewyk [sup.6] Author Affiliations: (1) https://ror.org/009xwd568, grid.412219.d, 0000 [...]
Background Rheumatoid arthritis (RA) is an inflammatory disease that can lead to progressive joint damage. Early identification of synovitis is key in the management of patients with RA. The aim of this study was to assess synovitis in patients with RA using .sup.99mTc-glucosamine single photon emission computed tomography/computed tomography (SPECT/CT) imaging and compare this radiopharmaceutical's diagnostic performance with ultrasound (US) imaging. This prospective study included 22 participants with active RA and 380 joints were assessed with SPECT/CT and US imaging. SPECT/CT imaging of the joints of interest was performed in each participant three hours after injection of .sup.99mTc-glucosamine, with US imaging of the same joints performed on the same day. The affected joints were qualitatively assessed for .sup.99mTc-glucosamine uptake and compared with the findings on US imaging. Results Abnormal increased uptake of .sup.99mTc-glucosamine, localized specifically to the synovial space, was noted in the affected joints. The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of .sup.99mTc-glucosamine SPECT/CT imaging were 86%, 60%, 61%, 85% and 73%, respectively. A sensitivity of 100% was noted in the identification of synovitis in the carpal and knee joints. Disease activity in the distal interphalangeal (DIP) joints was not observed with either SPECT/CT or US. Conclusions SPECT/CT imaging with .sup.99mTc-glucosamine is a valuable tool for assessing disease activity in the joints of patients with RA. It has a very high sensitivity in detecting synovitis and it correlates very well with US imaging in this regard.
Background Rheumatoid arthritis (RA) is an inflammatory disease that can lead to progressive joint damage. Early identification of synovitis is key in the management of patients with RA. The aim of this study was to assess synovitis in patients with RA using .sup.99mTc-glucosamine single photon emission computed tomography/computed tomography (SPECT/CT) imaging and compare this radiopharmaceutical's diagnostic performance with ultrasound (US) imaging. This prospective study included 22 participants with active RA and 380 joints were assessed with SPECT/CT and US imaging. SPECT/CT imaging of the joints of interest was performed in each participant three hours after injection of .sup.99mTc-glucosamine, with US imaging of the same joints performed on the same day. The affected joints were qualitatively assessed for .sup.99mTc-glucosamine uptake and compared with the findings on US imaging. Results Abnormal increased uptake of .sup.99mTc-glucosamine, localized specifically to the synovial space, was noted in the affected joints. The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of .sup.99mTc-glucosamine SPECT/CT imaging were 86%, 60%, 61%, 85% and 73%, respectively. A sensitivity of 100% was noted in the identification of synovitis in the carpal and knee joints. Disease activity in the distal interphalangeal (DIP) joints was not observed with either SPECT/CT or US. Conclusions SPECT/CT imaging with .sup.99mTc-glucosamine is a valuable tool for assessing disease activity in the joints of patients with RA. It has a very high sensitivity in detecting synovitis and it correlates very well with US imaging in this regard.