학술논문
An Experimental Study in an Induced Lung Injury Model in Sheep to Test a Novel Compression Ventilator
RESEARCH ARTICLE
RESEARCH ARTICLE
Document Type
Report
Author
Source
Cyprus Journal of Medical Sciences. April 2023, Vol. 8 Issue 2, p102, 6 p.
Subject
Language
English
ISSN
2149-7893
Abstract
INTRODUCTION Mechanical ventilation is one of the most common interventions implemented in critical respiratory care. More than half of the patients in the intensive care unit (ICU) are ventilated within [...]
BACKGROUND/AIMS: In a critical care setting, a simple, non-complex but reliable mechanical ventilator would serve as a candidate device in saving human life and qualified medical resources. In this study, we aimed to evaluate the efficacy, safety and reliability of a novel simple mechanical ventilator (ASC-1) developed for ventilation in an induced lung injury model and to compare the normal physiologic lung condition with an induced pathologic lung condition in sheep. MATERIALS AND METHODS: A sheep ventilation model was established in three female sheep which were anesthetized and intubated. Sheep A was ventilated with a conventional mechanical ventilator, Sheep B was ventilated with ASC-1 accordingly to the protective ventilation protocols. The lung injury model was induced with saline lavage in Sheep C. Following this, the animal was ventilated with ASC-1. At the end of 12 hours, the sheep were euthanized under anesthesia. The vital signs and changes in their arterial blood gas (ABG) were recorded. RESULTS: The biopsies collected from lungs were examined histologically. The injury and ventilation status of the lungs were examined radiographically. During the ventilation, all sheep maintained stable fluid-electrolyte balance and ABG, and no catastrophic events occurred in any of the sheep. The respiratory parameters of Sheep A were stabilized easily with an intensive care unit ventilator. Additionally, the parameters of Sheep B and Sheep C were also stabilized with the ASC-1 ventilator, at least clinically. The histological findings of the tissues were comparable between the three sheep. CONCLUSION: As a safe, reliable, low-cost ventilator, the ASC-1 ventilator may be a good alternative to be used in critical respiratory care per se, resulting in no further lung damage, especially in pandemic conditions where shortages of ventilators may be problematic. Keywords: Critical care, mechanical ventilation, animal model, sheep, lung injury
BACKGROUND/AIMS: In a critical care setting, a simple, non-complex but reliable mechanical ventilator would serve as a candidate device in saving human life and qualified medical resources. In this study, we aimed to evaluate the efficacy, safety and reliability of a novel simple mechanical ventilator (ASC-1) developed for ventilation in an induced lung injury model and to compare the normal physiologic lung condition with an induced pathologic lung condition in sheep. MATERIALS AND METHODS: A sheep ventilation model was established in three female sheep which were anesthetized and intubated. Sheep A was ventilated with a conventional mechanical ventilator, Sheep B was ventilated with ASC-1 accordingly to the protective ventilation protocols. The lung injury model was induced with saline lavage in Sheep C. Following this, the animal was ventilated with ASC-1. At the end of 12 hours, the sheep were euthanized under anesthesia. The vital signs and changes in their arterial blood gas (ABG) were recorded. RESULTS: The biopsies collected from lungs were examined histologically. The injury and ventilation status of the lungs were examined radiographically. During the ventilation, all sheep maintained stable fluid-electrolyte balance and ABG, and no catastrophic events occurred in any of the sheep. The respiratory parameters of Sheep A were stabilized easily with an intensive care unit ventilator. Additionally, the parameters of Sheep B and Sheep C were also stabilized with the ASC-1 ventilator, at least clinically. The histological findings of the tissues were comparable between the three sheep. CONCLUSION: As a safe, reliable, low-cost ventilator, the ASC-1 ventilator may be a good alternative to be used in critical respiratory care per se, resulting in no further lung damage, especially in pandemic conditions where shortages of ventilators may be problematic. Keywords: Critical care, mechanical ventilation, animal model, sheep, lung injury