부산대학교 도서관

Background: Toddlers with asthma suffer disproportionally more than school-aged children from exacerbations with emergency visits and hospital admissions despite inhaled corticosteroid (ICS) treatment. A recent trial for children [less than or equal to]5 years showed tolerability of tiotropium and potential to reduce asthma-related events. Methods: We conducted a retrospective analysis of electronic outpatient records (2017-2019) of children Results: Compared with a mean 2.42 (95% CI: 1.75, 3.36) SCS courses per patient within 6 months prior to ICS/LABA/tiotropium, 0.74 (95% CI: 0.25, 1.08) SCS courses per patient were prescribed within 6 months after starting ICS/LABA/tiotropium (P Interpretation: Our retrospective study showed that adding tiotropium to ICS/LABA is a new treatment option for patients with severe preschool asthma; however, larger confirmatory studies are needed. Keywords: preschool asthma, severe uncontrolled asthma, tiotropium, inhaled steroids, long-acting [[beta.sub.2]-agonists, LABAs
Introduction Asthma is the most common chronic disease in children, imposing a high lifetime burden on individuals, their caregivers and healthcare systems. (1) Asthma is one of the main causes [...]