학술논문
Tom5 functionally links mitochondrial preprotein receptors to the general import pore
Document Type
Academic Journal
Author
Source
Nature. July 10, 1997, Vol. 388 Issue 6638, p195, 6 p.
Subject
Language
ISSN
0028-0836
Abstract
Scientists have discovered that the multisubunit preprotein translocase protein Tom5 has key function in the importation of pre-proteins as they travel towards mitochondrial subcompartments within the cell. Tom5 receptors help preproteins through the general import pore. The Tom5 protein has a single membrane anchor and a negatively-charged cytosolic segment. The research indicates that Tom5 acts as an 'acid chain' which directs the mitochondrial targeting process.