학술논문
Relationship between transforming growth factor [beta]1 and progression of hypertensive renal disease
Document Type
Academic Journal
Author
Source
Journal of Human Hypertension. Sept, 2002, Vol. 16 Issue 9, p641
Subject
Language
English
ISSN
0950-9240
Abstract
In this study the role of circulating transforming growth factor [beta]1 (TGF[beta]1) on progression of renal hypertensive disease has been investigated. Fifty consecutive outpatients with essential hypertension were enrolled and divided into three groups, according to their urinary albumin excretion (UAE). Group A comprised 10 hypertensives with UAE [les]20 mg/24 h (normoalbuminuric group); Group B included 21 hypertensives with UAE [greater than] 20 [less than] 300 mg/24 h (microalbuminuric group); Group C encompassed 19 hypertensives with UAE [??] 300 mg/24 h (proteinuric group). In all patients UAE by immunonephelometric assay, circulating TGF[beta]1 by a solid phase specific sandwich ELISA technique, BUN and creatinine by routine laboratory methods were determined. In addition, left ventricular telediastolic internal diameter, interventricular septum diastolic (IVSTd), posterior wall thickness, total and normalised to height[sup.2.7]left ventricular mass, relative wall thickness and left ventricular ejection fraction by M-B Mode echocardiography were calculated. Our results indicated that TGF[beta]1 levels were significantly (P[less than] 0.05) higher in Group B and C than Group A and in Group C than Group B. In addition IVSTd values were significantly (P[less than] 0.05) higher in both Group B and C than Group A. An evident, but not significant, higher prevalence of subjects with left ventricular hypertrophy were observed in Group C as compared with other groups. In all hypertensive subjects TGF[beta]1 correlated directly with UAE (P[less than] 0.0001) but not with BMI, LVM/h[sup.2.7]and mean blood pressure. Our data indicated that TGF[beta]1 might be considered a useful marker to evaluate the severity and progression of hypertensive renal disease. Additional long-term clinical data are needed to evaluate whether inhibition of TGF[beta]1 system may prolong the time to the ESRD in hypertensive patients. Journal of Human Hypertension(2002) 16:, 641-645. doi:10.1038/sj.jhh.1001465 Keywords: hypertensive renal disease, TGF[beta]1, urinary albumin excretion, left ventricular hypertrophy
Author(s): R Scaglione [1]; C Argano [2]; G Parrinello [2]; D Colomba [2]; T Di Chiara [2]; A Ferrante [2]; V Di Garbo [2]; G Avellone [2]; G Licata [2] [...]
Author(s): R Scaglione [1]; C Argano [2]; G Parrinello [2]; D Colomba [2]; T Di Chiara [2]; A Ferrante [2]; V Di Garbo [2]; G Avellone [2]; G Licata [2] [...]