학술논문
A pediatric case of SAPHO-CNO syndrome with clinical correlation between cutaneous and osteoarticular features
synovitis acne pustulosis hyperostosis osteitis-chronic non-bacterial osteomyelitis
synovitis acne pustulosis hyperostosis osteitis-chronic non-bacterial osteomyelitis
Document Type
Clinical report
Author
Source
European Journal of Rheumatology. October 2020, Vol. 7 Issue 4, p195, 4 p.
Subject
Language
English
ISSN
2147-9720
Abstract
Introduction In 1972 Giedion et al. (1) detailed a syndrome of acquired, aseptic, multifocal osteomyelitis of insidious onset and chronic course, characterized by unpredictable episodes of exacerbation and relapse in [...]
Synovitis acne pustulosis hyperostosis osteitis (SAPHO) and chronic nonbacterial osteomyelitis (CNO) represent overlapping osteoarticular autoinflammatory syndromes, with a minority displaying neutrophilic skin features at the time of diagnosis. The pathophysiological link and chronological timeframe between skin and osteoarticular findings remain ambiguous, which in turn can manifest in diagnostic delay. We present a rare pediatric case of SAPHO-CNO with a clear association between cutaneous and osteoarticular symptoms, treated with nonsteroidal anti-inflammatory medications, corticosteroids, and intravenous pamidronate. By raising physician awareness of these syndromes, we hope that appropriate management will be initiated in a more timely fashion avoiding unnecessary investigations and treatment. Keywords: SAPHO, CRMO, CNO, osteomyelitis, pustulosis, neutrophilic dermatoses
Synovitis acne pustulosis hyperostosis osteitis (SAPHO) and chronic nonbacterial osteomyelitis (CNO) represent overlapping osteoarticular autoinflammatory syndromes, with a minority displaying neutrophilic skin features at the time of diagnosis. The pathophysiological link and chronological timeframe between skin and osteoarticular findings remain ambiguous, which in turn can manifest in diagnostic delay. We present a rare pediatric case of SAPHO-CNO with a clear association between cutaneous and osteoarticular symptoms, treated with nonsteroidal anti-inflammatory medications, corticosteroids, and intravenous pamidronate. By raising physician awareness of these syndromes, we hope that appropriate management will be initiated in a more timely fashion avoiding unnecessary investigations and treatment. Keywords: SAPHO, CRMO, CNO, osteomyelitis, pustulosis, neutrophilic dermatoses