학술논문
Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?
Original investigation
Original investigation
Document Type
Academic Journal
Source
Journal of Basic and Clinical Health Sciences. January 2020, Vol. 4 Issue 1, p38, 6 p.
Subject
Language
English
ISSN
2458-8938
Abstract
INTRODUCTION Ischemic cerebrovascular disease is a disorder which can be fatal or physically dysfunctional affecting both the person and the environment. According to the infarct types and related factors prognosis [...]
Background: We investigated the association of monocyte to high-density lipoprotein cholesterol (HDL) ratio (MHR), neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ratio (LMR) with prognostic value and infarct types in patients with acute ischemic cerebrovascular disease (CVD). Matherial and Methods: The study was carried out retrospectively in 223 patients, but after the exclusion criterion, 150 patients with acute ischemic CVD were included to the study. The complete blood count and lipid profile were examined at the admission of the patients. For initial neurologic status, National Institutes of Health Stroke Scale (NIHSS) score and for following-up, modified Rankin Scale (mRS) score were evaluated. After the etiological investigations and neuroimaging, infarct types were defined. Results: We found that as the NIHSS score increased, LMR values decreased and NLR values increased statistically (p=0.02, p=0.013). Additionally, statistical significant differences were determined between MHR values and mRS scores (p=0.045). According to the results of regression analysis, it was observed that the increase of MHR was statistically significant on the MRS of people with cardioembolic infarction (p=0.004, StB=0.383). Conclusion: Our study provides, LMR and NLR values are related with the initial neurologic state, and they would be prognostic markers for the neurological deficit of acute cerebrovascular disease. MHR can be a follow-up marker for CVD and also a predictable marker for cardioembolic infarct type. Key words: Acute ischemic cerebrovascular disease, monocyte to high-density lipoprotein cholesterol ratio, neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio, prognosis.
Background: We investigated the association of monocyte to high-density lipoprotein cholesterol (HDL) ratio (MHR), neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ratio (LMR) with prognostic value and infarct types in patients with acute ischemic cerebrovascular disease (CVD). Matherial and Methods: The study was carried out retrospectively in 223 patients, but after the exclusion criterion, 150 patients with acute ischemic CVD were included to the study. The complete blood count and lipid profile were examined at the admission of the patients. For initial neurologic status, National Institutes of Health Stroke Scale (NIHSS) score and for following-up, modified Rankin Scale (mRS) score were evaluated. After the etiological investigations and neuroimaging, infarct types were defined. Results: We found that as the NIHSS score increased, LMR values decreased and NLR values increased statistically (p=0.02, p=0.013). Additionally, statistical significant differences were determined between MHR values and mRS scores (p=0.045). According to the results of regression analysis, it was observed that the increase of MHR was statistically significant on the MRS of people with cardioembolic infarction (p=0.004, StB=0.383). Conclusion: Our study provides, LMR and NLR values are related with the initial neurologic state, and they would be prognostic markers for the neurological deficit of acute cerebrovascular disease. MHR can be a follow-up marker for CVD and also a predictable marker for cardioembolic infarct type. Key words: Acute ischemic cerebrovascular disease, monocyte to high-density lipoprotein cholesterol ratio, neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio, prognosis.