학술논문
The Use of Self-Expanding Stents in Esophageal and Gastroesophageal Junction Cancer Palliation: A Meta-Analysis and Meta-Regression Analysis of Outcomes
Review
Review
Document Type
Clinical report
Author
Source
Digestive Diseases and Sciences. November 2010, Vol. 55 Issue 11, p3018, 13 p.
Subject
Language
English
ISSN
0163-2116
Abstract
Author(s): George Sgourakis [sup.1] [sup.2], Ines Gockel [sup.2], Arnold Radtke [sup.2], Georgia Dedemadi [sup.1], Konstantinos Goumas [sup.1], Sofia Mylona [sup.1], Hauke Lang [sup.2], Achilleas Tsiamis [sup.3], Constantine Karaliotas [sup.1] Author [...]
Background The objective of this study was to examine the impact of self-expanding stents versus locoregional treatment modalities in the setting of esophageal cancer palliation. Methods The present meta-analysis pooled the effects of outcomes of 1,027 patients enrolled in 16 randomized controlled trials. Results The meta-analysis revealed an advantage to the use of stents compared to locoregional modality treatments with respect to the number of patients requiring reinterventions, although the latter treatment arm had a higher 1-year survival. No difference was observed between the use of the antireflux stents and conventional stents in relieving reflux. Previous chemoradiotherapy had no impact on complications, procedural deaths, and overall patient survival. Differences in outcomes among stents were minimal. Conclusions Conventional self-expanding stents and anti-reflux stents are equally effective. Although the risk difference for 1-year survival favoured locoregional palliative treatment modalities, the latter were associated with a higher number of patients requiring reintervention.
Background The objective of this study was to examine the impact of self-expanding stents versus locoregional treatment modalities in the setting of esophageal cancer palliation. Methods The present meta-analysis pooled the effects of outcomes of 1,027 patients enrolled in 16 randomized controlled trials. Results The meta-analysis revealed an advantage to the use of stents compared to locoregional modality treatments with respect to the number of patients requiring reinterventions, although the latter treatment arm had a higher 1-year survival. No difference was observed between the use of the antireflux stents and conventional stents in relieving reflux. Previous chemoradiotherapy had no impact on complications, procedural deaths, and overall patient survival. Differences in outcomes among stents were minimal. Conclusions Conventional self-expanding stents and anti-reflux stents are equally effective. Although the risk difference for 1-year survival favoured locoregional palliative treatment modalities, the latter were associated with a higher number of patients requiring reintervention.