학술논문
Conformational change in antithrombin induced by heparin, probed with a monoclonal antibody against the 1C/4B region
Document Type
Academic Journal
Author
Source
Biochemistry. April 12, 1994, Vol. 33 Issue 14, p4375, 9 p. table
Subject
Language
ISSN
0006-2960
Abstract
Monoclonal antibody (MAb) probe of the structural changes induced by heparin in antithrombin reveals the spatial separation of thrombin binding region and increases 1C/4B region. The MAb inhibits the antithrombin action against thrombin without affecting the heparin cofactor activity against thrombin. S-carboxy methylated antithrombin does not react with MAb. A mobile reactive loop is associated with the heparin-binding site.