학술논문
Blood myxovirus resistance protein‐1 measurement in the diagnostic work‐up of suspected COVID‐19 infection in the emergency department
Document Type
Clinical report
Author
Source
Immunity, Inflammation and Disease. April 2022, Vol. 10 Issue 4
Subject
Language
English
Abstract
INTRODUCTION Coronavirus disease (COVID‐19) caused by the novel Coronavirus (SARS‐CoV‐2) causes a high burden on hospital capacities worldwide, especially at the emergency department (ED).[sup.1] Patients with a suspected COVID‐19 infection [...]
: Introduction: Myxovirus resistance protein 1 (MxA) is a biomarker that is elevated in patients with viral infections. The goal of this study was to evaluate the diagnostic value of MxA in diagnosing COVID‐19 infections in the emergency department (ED) patients. Methods: This was a single‐center prospective observational cohort study including patients with a suspected COVID‐19 infection. The primary outcome of this study was a confirmed COVID‐19 infection by RT‐PCR test. MxA was assessed using an enzyme immunoassay on whole blood and receiver operating chart and area under the curve (AUC) analysis was conducted. Sensitivity, specificity, negative predictive value, and positive predictive value of MxA on diagnosing COVID‐19 at the optimal cut‐off of MxA was determined. Results: In 2021, 100 patients were included. Of these patients, 77 patients had COVID‐19 infection and 23 were non‐COVID‐19. Median MxA level was significantly higher (p Conclusion: MxA accurately distinguishes COVID‐19 infections from bacterial infections and noninfectious diagnoses in the ED in patients with a suspected COVID‐19 infection. If the results can be validated, MxA could improve the diagnostic workup and patient flow in the ED.
: Introduction: Myxovirus resistance protein 1 (MxA) is a biomarker that is elevated in patients with viral infections. The goal of this study was to evaluate the diagnostic value of MxA in diagnosing COVID‐19 infections in the emergency department (ED) patients. Methods: This was a single‐center prospective observational cohort study including patients with a suspected COVID‐19 infection. The primary outcome of this study was a confirmed COVID‐19 infection by RT‐PCR test. MxA was assessed using an enzyme immunoassay on whole blood and receiver operating chart and area under the curve (AUC) analysis was conducted. Sensitivity, specificity, negative predictive value, and positive predictive value of MxA on diagnosing COVID‐19 at the optimal cut‐off of MxA was determined. Results: In 2021, 100 patients were included. Of these patients, 77 patients had COVID‐19 infection and 23 were non‐COVID‐19. Median MxA level was significantly higher (p Conclusion: MxA accurately distinguishes COVID‐19 infections from bacterial infections and noninfectious diagnoses in the ED in patients with a suspected COVID‐19 infection. If the results can be validated, MxA could improve the diagnostic workup and patient flow in the ED.