학술논문
The Effectiveness of the Serum Neutrophil-lymphocyte Ratio in the Determination of an Advanced Stage in Colorectal Cancers
RESEARCH ARTICLE
RESEARCH ARTICLE
Document Type
Report
Source
Turkish Journal of Colorectal Disease. March 2023, Vol. 33 Issue 1, p25, 6 p.
Subject
Language
English
ISSN
2536-4898
Abstract
Introduction Colorectal cancer (CRC) is one of the most common types of cancer worldwide. (1) Despite the advancement of new therapeutic strategies in surgery, chemotherapy, radiotherapy, and molecular therapy, the [...]
Aim: Patients with colorectal cancer (CRC) have a poor prognosis in the advanced stages. Although advanced imaging methods contribute to the diagnosis process, there is a need for potential biomarkers to help identify patients with poor prognoses. The neutrophil-lymphocyte ratio (NLR) is one of these potential biomarkers, and many studies have found that a high NLR is a predictive marker for a poor prognosis in various cancers. This study aims to determine whether there is a relationship between the NLR and the tumor stage in CRC patients. Method: We retrospectively assessed patients who underwent elective curative resection for CRC between January 2016 and July 2019. The demographic information, preoperative NLR, and detailed pathological data were recorded and analyzed. The study's primary aim was to investigate whether there was a relationship between the pathological stage and the NLR. The secondary aim was to examine the relationship between the number of positive and removed lymph nodes, tumor biology, and the NLR. Results: No statistically significant correlation existed between the tumor stage, the number of positive and removed lymph nodes, and the NLR. However, a statistically significant negative correlation was found between tumor differentiation and the NLR. Conclusion: Although a relationship between the tumor stage and the NLR was shown in the authors' study, this did not reach the level of statistical significance. Likewise, there was no significant relationship between the lymph node involvement and the NLR; only the degree of differentiation of the tumor and the NLR were significantly correlated. Therefore, prospective randomized studies with large patient cohorts would be useful in evaluating the clinical use of the NLR in CRC. Keywords: Colorectal cancer, neutrophil-lymphocyte ratio, stage, survival, differentiation, lymphatic infiltration, vascular invasion, perineural invasion
Aim: Patients with colorectal cancer (CRC) have a poor prognosis in the advanced stages. Although advanced imaging methods contribute to the diagnosis process, there is a need for potential biomarkers to help identify patients with poor prognoses. The neutrophil-lymphocyte ratio (NLR) is one of these potential biomarkers, and many studies have found that a high NLR is a predictive marker for a poor prognosis in various cancers. This study aims to determine whether there is a relationship between the NLR and the tumor stage in CRC patients. Method: We retrospectively assessed patients who underwent elective curative resection for CRC between January 2016 and July 2019. The demographic information, preoperative NLR, and detailed pathological data were recorded and analyzed. The study's primary aim was to investigate whether there was a relationship between the pathological stage and the NLR. The secondary aim was to examine the relationship between the number of positive and removed lymph nodes, tumor biology, and the NLR. Results: No statistically significant correlation existed between the tumor stage, the number of positive and removed lymph nodes, and the NLR. However, a statistically significant negative correlation was found between tumor differentiation and the NLR. Conclusion: Although a relationship between the tumor stage and the NLR was shown in the authors' study, this did not reach the level of statistical significance. Likewise, there was no significant relationship between the lymph node involvement and the NLR; only the degree of differentiation of the tumor and the NLR were significantly correlated. Therefore, prospective randomized studies with large patient cohorts would be useful in evaluating the clinical use of the NLR in CRC. Keywords: Colorectal cancer, neutrophil-lymphocyte ratio, stage, survival, differentiation, lymphatic infiltration, vascular invasion, perineural invasion